Th1/Th2 cytokine profile in patients coinfected with HIV and Leishmania in Brazil.

Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
University of California. San Diego, La Jolla, California
University of California. San Diego, La Jolla, California
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
University of California. San Diego, La Jolla, California
Universidade Federal da Bahia. Salvador, BA, Brasil / University of California. San Diego, La Jolla, California

Abstract

To evaluate the effects of HIV on immune responses in cutaneous leishmaniasis (CL), we quantified cytokine levels from plasma and stimulated peripheral blood mononuclear cells (PBMCs) from individuals infected with HIV and/or CL. Gamma interferon (IFN- ) and interleukin 13 (IL-13) levels and the ratio of IFN- to IL-10 produced in response to stimulation with soluble Leishmania antigens were significantly lower in HIV-Leishmania-coinfected patients than in CL-monoinfected patients.

DeCS

Citocinas/sangue
Infecções por HIV/complicações
Infecções por HIV/imunologia
Leishmaniose Cutânea/complicações
Leishmaniose Cutânea/imunologia
Células Th1/imunologia
Células Th2/imunologia
Brasil
Células Cultivadas
Citocinas/secreção
Humanos
Leucócitos Mononucleares/imunologia
Plasma/química

Publisher

American Society for Microbiology

Citation

RODRIGUES, M. Z. et al. Th1/Th2 cytokine profile in patients coinfected with HIV and Leishmania in Brazil. Clinical Vaccine Immunology, v. 18, n. 10, p. 1765-1769, 2011.

DOI

10.1128/CVI.00076-11

ISSN

1556-679X

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8507

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