Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/8456
HTLV-1 AND TUBERCULOSIS ASSOCIATION A REVIEW OF THE LITERATURE
Tuberculosis
Prevalence
Immune response
Review
Autor(es)
Afiliação
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Human Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Resumo em Inglês
Objective: To review and evaluate the scientific evidences on the relationship between tuberculosis
(TB) and HTLV-1 infection. Methods: Searches on MEDLINE, LILACS/SciELO and Cochrane Library
databases were performed using the following keywords: HTLV-1 Infection, Human T-lymphotropic
virus type 1; Paraparesis Tropical Spastic; Tuberculosis. The following data were evaluated: Study design,
sample size, number of controls, frequency of HTLV-1 infection in patients with TB and uninfected
controls, mortality in HTLV-1/TB coinfected individuals compared with controls group, response in vivo
and in vitro to PPD, frequency of individuals with tuberculin skin test (TST) positive or negative. Results:
Nineteen articles were selected: twelve investigated prevalence, four mortality, three evaluated both
prevalence and mortality and six described immunological findings. The majority of the studies was
conducted in South America (Brazil and Peru), and Japan. Seven out of 12 studies found an increased
risk of HTLV-1 in patients with TB diagnosis. The prevalence of HTLV-1/TB co-infection ranged from
1.49 % in Brazil to 11.4 % in patients in Peru. Two out of five studies found a higher mortality of patients
with HTLV-1/TB co-infection compared to patients with TB alone. Three studies conducted in Africa (Guinea Bissau and Senegal) found no increase in the mortality of patients co-infected with TB and HTLV-1. A
decreased response to PPD in vitro or in vivo was observed in co-infected individuals compared with patients
with TB alone. Conclusion: Patients with TB diagnosis have a higher prevalence of HTLV-1, compared with
uninfected controls. Co-infection HTLV-1/TB increases the mortality of TB
Palavras-chave em inglês
Human T-Lymphotropic Virus-1 (HTLV-1)Tuberculosis
Prevalence
Immune response
Review
Compartilhar