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https://www.arca.fiocruz.br/handle/icict/8401
SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY-LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE
Hipersensibilidade Tardia/patologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Feminino
Interferon gama/biossíntese
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Afiliação
University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
Colorado State University. Department of Pathology. Fort Collins, Colorado
Centocor, Incorporated, Infectious Diseases. Malvern, Pennsylvania
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Colorado State University. Department of Pathology. Fort Collins, Colorado
Colorado State University. Department of Pathology. Fort Collins, Colorado
Centocor, Incorporated, Infectious Diseases. Malvern, Pennsylvania
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Colorado State University. Department of Pathology. Fort Collins, Colorado
Resumo em Inglês
B cell-deficient C57Bl/6 ( MT) mice were resistant to Leishmania major after both primary and secondary
parasite challenge. However, unlike in wild-type mice, secondary infection in MT mice was not accompanied by a
marked delayed type hypersensitivity-like response, and interferon- (IFN- ) levels were approximately half of those in
wild-type mice. These results suggest that B cells are involved in IFN- production and the pathology of secondary
infection.
DeCS
Linfócitos B/imunologiaHipersensibilidade Tardia/patologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Feminino
Interferon gama/biossíntese
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
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