Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/8189
Tipo
ArtículoDerechos de autor
Acceso abierto
Colecciones
- BA - IGM - Artigos de Periódicos [3674]
- INI - Artigos de Periódicos [3460]
- IOC - Artigos de Periódicos [12642]
Metadatos
Mostrar el registro completo del ítem
NEUTRALIZATION SUSCEPTIBILITY OF B SUBTYPE VARIANT B" PRIMARY HIV-1 ISOLATES. THE HEC/FIOCRUZ AIDS CLINICAL RESEARCH GROUP
HIV-1
Variação Antigênica
Anticorpos Anti-HIV
Isolamento & purificação
Testes de Neutralização
Humanos
Autor
Afiliación
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Servidores do Estado Hospital Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Servidores do Estado Hospital Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Oswaldo Cruz Foundation. Evandro Chagas Hospital. AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Institute Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to the classical B-subtype HIV-1 isolates was observed. Comparisons of neutralization susceptibilities were carried out for 19 B-subtype, 11 B"-variant and two F-subtype HIV-1 isolates with plasma from autologous and heterologous samples. Frequency of autologous neutralization was slightly lower for B-subtype isolates in comparison to B"-variant isolates. Heterologous intra-subtype neutralization was significantly lower for B-subtype than for the B"-variant or the F-subtype isolates. While B-subtype isolates were neutralized by most anti-F-subtype plasma, F-subtype isolates, although most susceptible to F-subtype antibodies, were highly susceptible to neutralization by anti-B-subtype antibodies. Cross-neutralization for B"-variant and B-subtype isolates was not as extensive as observed for B- and F-subtype isolates. However, the results presented indicate a quite extensive cross-neutralization between Brazilian HIV-1 isolates.
DeCS
Antígenos HIVHIV-1
Variação Antigênica
Anticorpos Anti-HIV
Isolamento & purificação
Testes de Neutralização
Humanos
Compartir