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THE LOW EVOLUTIONARY RATE OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 CONFIRMED BY ANALYSIS OF VERTICAL TRANSMISSION CHAINS
Vírus 1 Linfotrópico T Humano/genética
Transmissão Vertical de Doença Infecciosa
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/transmissão
Humanos
Funções Verossimilhança
Masculino
Meia-Idade
Mutação
Linhagem
Filogenia
Distribuição de Poisson
Autor(es)
Afiliação
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
University of Oxford. Department of Zoology. Oxford, U.K.
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
Department of Medical Research. Mackay Memorial Hospital. Taipei, Taiwan.
Universite´ Catholique de Louvain. Unité de Virologie. Bruxelles, Belgium.
Hospital San Roque. San Salvador de Jujuy, Argentina.
Institut Pasteur de la Guyane. Laboratoire de Rétrovirologie. Cayenne, French Guiana.
Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
University of Oxford. Department of Zoology. Oxford, U.K.
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
Department of Medical Research. Mackay Memorial Hospital. Taipei, Taiwan.
Universite´ Catholique de Louvain. Unité de Virologie. Bruxelles, Belgium.
Hospital San Roque. San Salvador de Jujuy, Argentina.
Institut Pasteur de la Guyane. Laboratoire de Rétrovirologie. Cayenne, French Guiana.
Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
Resumo em Inglês
The evolutionary rate of the human T-cell lymphotropic virus type-1 (HTLV-1) is considered to be very low, in strong contrast to the related human retrovirus HIV. However, current estimates of the HTLV-1 rate rely on the anthropological calibration of phylogenies using assumed dates of human migration events. To obtain an independent rate estimate, we analyzed two variable regions of the HTLV-1 genome (LTR and env) from eight infected families. Remarkable genetic stability was observed, as only two mutations in LTR (756 bp) and three mutations in env (522 bp) occurred within the 16 vertical transmission chains, including one ambiguous position in each region. The evolutionary rate in HTLV-1 was then calculated using a maximum-likelihood approach that used the highest and lowest possible times of HTLV-1 shared ancestry, given the known transmission histories. The rates for the LTR and env regions were 9.58 3 10 8–1.25 3 10 5 and 7.84310 7 –2.33310 5nucleotide substitutions per site per year, respectively. A more precise estimate was obtained for the combined LTR-env data set, which was 7.06310 7–1.38310 5substitutions per site per year. We also
note an interesting correlation between the occurrence of mutations in HTLV-1 and the age of the individual infected.
DeCS
Evolução BiológicaVírus 1 Linfotrópico T Humano/genética
Transmissão Vertical de Doença Infecciosa
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/transmissão
Humanos
Funções Verossimilhança
Masculino
Meia-Idade
Mutação
Linhagem
Filogenia
Distribuição de Poisson
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