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https://www.arca.fiocruz.br/handle/icict/8085
STUDY OF AUTOANTIBODIES IN PATIENTS WITH KERATOCONJUNCTIVITIS SICCA INFECTED BY THE HUMAN T CELL LYMPHOTROPIC VIRUS TYPE 1.
Infecções por HTLV-I/complicações
Ceratoconjuntivite Seca/imunologia
Adulto
Idoso
Anticorpos Antinucleares/análise
Anticorpos Antinucleares/sangue
Autoanticorpos/análise
Marcadores Biológicos/análise
Brasil
Estudo de Coortes
Feminino
Humanos
Imunidade Humoral/fisiologia
Ceratoconjuntivite Seca/sangue
Masculino
Meia-Idade
Provirus/imunologia
Fator Reumatoide/análise
Ribonucleoproteínas/imunologia
Carga Viral
Author
Affilliation
Instituto Brasileiro de Oftalmologia e Prevenção à Cegueira. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Universidade Federal da Bahia. Immunology Research Laboratory. Clinical and Toxicological Analysis. Faculty of Pharmacy. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Serviço de Reumatologia do HSI. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Federal da Bahia. Immunology Research Laboratory. Clinical and Toxicological Analysis. Faculty of Pharmacy. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Serviço de Reumatologia do HSI. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Abstract
Human T cell lymphotropic virus type 1
(HTLV-1) is endemic in many regions of the world, including
Brazil, and has been associated to several immunological
manifestations such as arthritis, uveitis, dermatitis and
Sjögren’s syndrome. This study was intended to evaluate
the frequency of autoantibodies in patients infected with
HTLV-1 and manifesting keratoconjunctivitis sicca (KCS).
HTLV-1 patients with KCS, enrolled in a reference ambulatory
of the city of Salvador, were tested for autoantibodies
such as antinuclear antibodies, rheumatoid factor, anti-
SSA/Ro and anti-SSB/La. Two comparison groups were
also included: (a) HTLV-1 patients without KCS and (b)
seronegative patients with KCS. Correlation of proviral
load (PVL) in HTLV-1 patients with presence or absence of
KCS was also assessed. No autoantibodies were detected in
HTLV-1 patients with KCS. The PVL of HTLV-1 patients
was higher in patients with KCS without other clinical
manifestations customarily associated to HTLV-1. In conclusion,
in this study, no changes were observed in humoral
immunity concerning production of certain autoantibodies
in HTLV-1-infected patients with KCS, which suggests that
other mechanisms may be involved in the pathogenesis of
this manifestation. Additionally, PVL may be a marker of
KCS development in these patients.
DeCS
Autoanticorpos/sangueInfecções por HTLV-I/complicações
Ceratoconjuntivite Seca/imunologia
Adulto
Idoso
Anticorpos Antinucleares/análise
Anticorpos Antinucleares/sangue
Autoanticorpos/análise
Marcadores Biológicos/análise
Brasil
Estudo de Coortes
Feminino
Humanos
Imunidade Humoral/fisiologia
Ceratoconjuntivite Seca/sangue
Masculino
Meia-Idade
Provirus/imunologia
Fator Reumatoide/análise
Ribonucleoproteínas/imunologia
Carga Viral
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