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ORAL HEALTH PROFILE IN PATIENTS INFECTED WITH HTLV-1: CLINICAL FINDINGS, PROVIRAL LOAD, AND MOLECULAR ANALYSIS FROM HTLV-1 IN SALIVA.
Vírus 1 Linfotrópico T Humano/genética
Paraparesia Espástica Tropical/virologia
Provirus/genética
Saliva/virologia
Carga Viral
Adolescente
Adulto
Estudos Transversais
DNA Viral/genética
Dieta Cariogênica
Feminino
Humanos
Leucócitos Mononucleares/virologia
Masculino
Meia-Idade
Doenças Periodontais/virologia
Salivação
Análise de Sequência de DNA
Adulto Jovem
Autor
Afiliación
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil
National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil
National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Resumen en ingles
Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV-1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV-1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra-host variations from peripheral blood mononuclear cells and saliva cells. It is a cross-sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV-1 positive and 30 were negative. Individuals from the HTLV-1 positive and negative groups had similar mean age and social-economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P < 0.05 were considered statistically significant. HTLV-1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV-1 carriers. The HTLV-1 molecular analysis from PBMC and saliva specimens suggests that HTLV-1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed.
DeCS
Portador Sadio/virologiaVírus 1 Linfotrópico T Humano/genética
Paraparesia Espástica Tropical/virologia
Provirus/genética
Saliva/virologia
Carga Viral
Adolescente
Adulto
Estudos Transversais
DNA Viral/genética
Dieta Cariogênica
Feminino
Humanos
Leucócitos Mononucleares/virologia
Masculino
Meia-Idade
Doenças Periodontais/virologia
Salivação
Análise de Sequência de DNA
Adulto Jovem
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