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https://www.arca.fiocruz.br/handle/icict/7867
COMPARATIVE STUDY OF THE EXPRESSION OF CELLULAR CYCLE PROTEINS IN CERVICAL INTRAEPITHELIAL LESIONS
Neoplasia Intraepitelial Cervical/metabolismo
Neoplasias do Colo do Útero/metabolismo
Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia
Proliferação de Células
Neoplasia Intraepitelial Cervical/patologia
Colo do Útero/anatomia & histologia
Colo do Útero/metabolismo
Ciclina D1/metabolismo
Inibidor p16 de Quinase Ciclina-Dependente/metabolismo
Feminino
Humanos
Antígeno Ki-67/metabolismo
Meia-Idade
Marcadores Biológicos de Tumor/metabolismo
Neoplasias do Colo do Útero/patologia
Autor(es)
Afiliação
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
São Paulo Federal University. Department of Pathology. Adolfo Lutz Institute. São Paulo, SP, Brasil
Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil
Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
São Paulo Federal University. Department of Pathology. Adolfo Lutz Institute. São Paulo, SP, Brasil
Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil
Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Interaction of human papilloma virus oncoproteins E6 and E7 with cell cycle proteins leads to disturbances of the
cell cycle mechanism and subsequent alteration in the expression of some proteins, such as p16INK4a, cyclin D1, p53
and KI67. In this study, we compared alterations in the expression of these proteins during several stages of intraepitelial
cervical carcinogenesis. Accordingly, an immunohistochemical study was performed on 50 cervical biopsies,
including negative cases and intraepithelial neoplasias. The expression patterns of these markers were correlated with
the histopathological diagnosis and infection with HPV. The p16INK4a, followed by Ki67, showed better correlation
with cancer progression than p53 and cyclin D1, which recommends their use in the evaluation of cervical
carcinogenesis. These monoclonal antibodies can be applied to cervical biopsy specimens to identify lesions
transformed by oncogenic HPV, separating CIN 1 (p16INK4a positive) and identifying high-grade lesions by an increase
in the cellular proliferation index (Ki67). In this way, we propose immunomarkers that can be applied in clinical
practice to separate patients who need a conservative therapeutic approach from those who require a more aggressive
treatment.
DeCS
Proteínas de Ciclo Celular/metabolismoNeoplasia Intraepitelial Cervical/metabolismo
Neoplasias do Colo do Útero/metabolismo
Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia
Proliferação de Células
Neoplasia Intraepitelial Cervical/patologia
Colo do Útero/anatomia & histologia
Colo do Útero/metabolismo
Ciclina D1/metabolismo
Inibidor p16 de Quinase Ciclina-Dependente/metabolismo
Feminino
Humanos
Antígeno Ki-67/metabolismo
Meia-Idade
Marcadores Biológicos de Tumor/metabolismo
Neoplasias do Colo do Útero/patologia
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