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CYTOTOXIC PROPERTIES OF THE LEAF ESSENTIAL OILS OF GUATTERIA BLEPHAROPHYLLA AND GUATTERIA HISPIDA (ANNONACEAE)
Guatteria hispida
Annonaceae
Cytotoxicity
Apoptosis
Autor(es)
Afiliação
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil
Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Guatteria blepharophylla Mart. (synonym Guatteriopsis blepharophylla Mart.) and Guatteria hispida (R.E. Fr.)
Erkens & Maas (synonym Guatteriopsis hispida R.E. Fr.) belong to the Annonaceae family and are found in the Brazilian
and Colombian Amazon basin. Both species are popularly known as ‘envira’ or ‘envireira’. In the present study, the leaf
essential oils of G. blepharophylla (EOGB) and G. hispida (EOGH) were selected to investigate their cytotoxic effects. Tumour
cell lines were treated with increasing concentrations of both essential oils for 72 h and analysed by a methyl-[3H]thymidine
incorporation assay. The pro-apoptotic effect of these essential oils was assessed in HepG2 cells by morphological analysis
(using haematoxylin/eosin staining and acridine orange/ethidium bromide staining), flow cytometry (cell membrane integrity
and internucleosomal DNA fragmentation analysis) and a caspase-3 activation assay after 24 h incubation. Both essential oils
displayed potent cytotoxicity in different tumour cell lines. EOGB showed IC50 values from 6.03 to 16.46 ìg/ml for HepG2 and
K562 cell lines, and EOGH showed IC50 values from 5.45 to 24.89 ìg/ml for HepG2 and K562 cell lines, respectively. Cell
morphologies consistent with apoptosis and a remarkable activation of caspase-3 were observed in the HepG2 cells treated
with essential oils for 24 h. Significant increases in internucleosomal DNA fragmentation without altered membrane integrity
were also found. In conclusion, both essential oils investigated were able to inhibit tumour cell proliferation and induce cell
death by apoptosis pathways.
Palavras-chave em inglês
Guatteria blepharophyllaGuatteria hispida
Annonaceae
Cytotoxicity
Apoptosis
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