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ASSOCIATION PHENOTHIAZINE AND LASER ON GROWTH OF C. TROPICALIS FLUCONAZOLE-RESISTANT
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Resumo em Inglês
Candidiasis is caused by Candida species found on the skin, gastrointestinal tract and mucous cavities of the humans and
may be acute, chronic, localized or systemic. Alhough C. albicans is the species most often identified as responsible for
this type of infection C. Tropicalis has been considered an emerging cause. The effect of the association of phenothiazine
- PTZ and laser on fluconazole-resistant C.tropicalis growth was tested. 2.5 x 106 CFU/mL 100mg/mL of phenothiazine
with the pre-irradiation time of 10 min were irradiated with laser light (660 nm; 4.8 and 12 J/cm2 (L1 and L2
respectively) 40 mW) followed by incubation in RPMI for 24h. The following conditions were tested: control (control),
laser (L1 and L2), phenothiazine (F1 and F2), and PACT (F1L1 and F2L2). Statistically significant diferences were seen
between groups (L-F +) and (F + L +) for both conditions of the laser, with a growth inhibition of the yeast around 67
and 51%, respectively, however, when using only the laser there was an increase of 18% in the survival of these cells.
PACT´s efficacy on fluconazole-resistant C. tropicalis depended on both the time of pre-irradiation and concentration of
the PTZ.
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