Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/7579
SOLUBLE INTERCELLULAR ADHESION MOLECULES IN HUMAN SCHISTOSOMIASIS: CORRELATIONS WITH DISEASE SEVERITY AND DECREASED RESPONSIVENESS TO EGG ANTIGENS
Moléculas de Adesão Celular/sangue
Proteínas do Ovo/imunologia
Granuloma/etiologia
Esquistossomose/metabolismo
Adolescente
Adulto
Animais
Moléculas de Adesão Celular/imunologia
Criança
Pré-Escolar
Selectina E
Feminino
Humanos
Molécula 1 de Adesão Intercelular
Ativação Linfocitária
Masculino
Meia-Idade
Contagem de Ovos de Parasitas
Schistosoma
Esquistossomose/complicações
Esquistossomose/imunologia
Solubilidade
Fator de Necrose Tumoral alfa/análise
Autor(es)
Afiliação
Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Roberto Santos. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Roberto Santos. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts
Resumo em Inglês
Granuloma formation, the principal pathologic consequence of infection with Schistosoma mansoni, is a
complex process involving intricate cell-cell interactions in which intercellular adhesion molecules are likely to
participate. To examine this possibility, sera of schistosomiasis patients in various clinical groups were assayed
for the presence of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin).
Comparisons were made between groups with different infection intensities (as predicted by fecal egg count)
as well as between groups with severe (hepatosplenic) or milder (intestinal) pathology. All groups had elevated
levels of sICAM-1 compared with controls. Also, patients in the high egg-excreting and hepatosplenic groups
had significantly higher levels of serum sICAM-1 than patients in the low-egg-excreting and intestinal groups,
respectively. The levels of sE-selectin were significantly elevated in the sera of all patients except those in the
hepatosplenic group compared with controls. Patients in the intestinal group had significantly higher levels of
sE-selectin in their sera than did hepatosplenic group patients, but serum sE-selectin levels of high- and
low-egg-excreting patients were comparable. A striking finding of this study was the inverse correlation
observed between sICAM-1 levels and peripheral blood mononuclear cell responses to schistosome soluble egg
antigens (SEA) but not with responses to other schistosome antigens, purified protein derivative, or mitogen.
Because ICAM-1 can perform a costimulatory function in antigen-presenting cell-T cell interactions, it is
possible that shedding of ICAM-1 in the granuloma microenvironment interrupts proper costimulation,
leading to unresponsive SEA-specific T cells. In this way, sICAM-1 could be one factor contributing to the
observed modulation of cellular responses to SEA in chronic human schistosomiasis.
DeCS
Antígenos de Helmintos/imunologiaMoléculas de Adesão Celular/sangue
Proteínas do Ovo/imunologia
Granuloma/etiologia
Esquistossomose/metabolismo
Adolescente
Adulto
Animais
Moléculas de Adesão Celular/imunologia
Criança
Pré-Escolar
Selectina E
Feminino
Humanos
Molécula 1 de Adesão Intercelular
Ativação Linfocitária
Masculino
Meia-Idade
Contagem de Ovos de Parasitas
Schistosoma
Esquistossomose/complicações
Esquistossomose/imunologia
Solubilidade
Fator de Necrose Tumoral alfa/análise
Compartilhar