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BIOCHEMICAL AND IMMUNOLOGIC PREDICTORS OF EFFICACY OF TREATMENT OR REINFECTION RISK FOR SCHISTOSOMA MANSONI.
Recidiva
Schistosoma mansoni/imunologia
Esquistossomose mansoni/fisiopatologia
Adolescente
Animais
Criança
Estudos de Coortes
Feminino
Humanos
Masculino
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/epidemiologia
Resultado do Tratamento
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. School of Nutrition. Salvador, BA, BRasil
Institute of Collective Health. Federal University of Bahia. Salvador, BA, Brasil
Department of Nutrition. Case Western Reserve University. Cleveland, Ohio
School of Nutrition. Federal University of Bahia. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Cornell Road. Building, Cleveland, Ohio
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. School of Nutrition. Salvador, BA, BRasil
Institute of Collective Health. Federal University of Bahia. Salvador, BA, Brasil
Department of Nutrition. Case Western Reserve University. Cleveland, Ohio
School of Nutrition. Federal University of Bahia. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Cornell Road. Building, Cleveland, Ohio
Resumo em Inglês
Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661
infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical
and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy
and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or
reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected
and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically
different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection
(100 versus 65 eggs/g, P 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL,
P 0.045). The biologic plausibility of this observation is discussed.
DeCS
Valor Preditivo dos TestesRecidiva
Schistosoma mansoni/imunologia
Esquistossomose mansoni/fisiopatologia
Adolescente
Animais
Criança
Estudos de Coortes
Feminino
Humanos
Masculino
Esquistossomose mansoni/quimioterapia
Esquistossomose mansoni/epidemiologia
Resultado do Tratamento
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