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BALB/C MICE VACCINATED WITH LEISHMANIA MAJOR RIBOSOMAL PROTEINS EXTRACTS COMBINED WITH CPG OLIGODEOXYNUCLEOTIDES BECOME RESISTANT TO DISEASE CAUSED BY A SECONDARY PARASITE CHALLENGE
Vacinas contra Leishmaniose/imunologia
Leishmaniose Cutânea/imunologia
Oligodesoxirribonucleotídeos/imunologia
Proteínas de Protozoários/imunologia
Proteínas Ribossômicas/imunologia
Animais
Antígenos de Protozoários/imunologia
Citocinas/imunologia
Citocinas/metabolismo
Modelos Animais de Doenças
Feminino
Vacinas contra Leishmaniose/farmacologia
Leishmaniose Cutânea/prevenção & controle
Camundongos
Camundongos Endogâmicos BALB C
10.1155/2010/181690
Autor(es)
Afiliação
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Unidad de Inmunología Viral. Majadahonda, Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Unidad de Inmunología Viral. Majadahonda, Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidad Autónoma de Madrid. Departamento de Biología Molecular. Centro de Biología Molecular Severo Ochoa. Madrid, Spain
Resumo em Inglês
Leishmaniasis is an increasing public health problem and effective vaccines are not currently available. We have previously
demonstrated that vaccination with ribosomal proteins extracts administered in combination of CpG oligodeoxynucleotides
protects susceptible BALB/c mice against primary Leishmania major infection. Here, we evaluate the long-term immunity to
secondary infection conferred by this vaccine.We show that vaccinated and infected BALB/c mice were able to control a secondary
Leishmania major challenge, since no inflammation and very low number of parasites were observed in the site of reinfection.
In addition, although an increment in the parasite burden was observed in the draining lymph nodes of the primary site of
infection we did not detected inflammatory lesions at that site. Resistance against reinfection correlated to a predominant Th1
response against parasite antigens. Thus, cell cultures established from spleens and the draining lymph node of the secondary site
of infection produced high levels of parasite specific IFN-γ in the absence of IL-4 and IL-10 cytokine production. In addition,
reinfected mice showed a high IgG2a/IgG1 ratio for anti-Leishmania antibodies. Our results suggest that ribosomal vaccine, which
prevents pathology in a primary challenge, in combination with parasite persistence might be effective for long term maintenance
of immunity.
DeCS
Leishmania major/imunologiaVacinas contra Leishmaniose/imunologia
Leishmaniose Cutânea/imunologia
Oligodesoxirribonucleotídeos/imunologia
Proteínas de Protozoários/imunologia
Proteínas Ribossômicas/imunologia
Animais
Antígenos de Protozoários/imunologia
Citocinas/imunologia
Citocinas/metabolismo
Modelos Animais de Doenças
Feminino
Vacinas contra Leishmaniose/farmacologia
Leishmaniose Cutânea/prevenção & controle
Camundongos
Camundongos Endogâmicos BALB C
Editor
Hindawi Publishing Corporation
Referência
RAMÍREZ, L. et al. BALB/c mice vaccinated with Leishmania major ribosomal proteins extracts combined with CpG oligodeoxynucleotides become resistant to disease caused by a secondary parasite challenge. Journal of Biomedicine and Biotechnology, p. 1-10, 2010.ISSN
1110-725110.1155/2010/181690
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