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LESION SIZE CORRELATES WITH LEISHMANIA ANTIGEN-STIMULATED TNF-LEVELS IN HUMAN CUTANEOUS LEISHMANIASIS
Leishmania/imunologia
Leishmaniose Cutânea/patologia
Fator de Necrose Tumoral alfa/metabolismo
Adolescente
Adulto
Idoso
Feminino
Humanos
Leishmaniose Cutânea/metabolismo
Meia-Idade
Masculino
Autor
Afiliación
Resumen en ingles
Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark
of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as
tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the
impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an
endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological
evaluations in a 2-year period. Statistical analysis revealed that healing time ( P = 0.029), age ( P = 0.002), and TNF levels
( P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer
size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to
improve healing in CL patients with severe lesions
DeCS
Antígenos de Protozoários/imunologiaLeishmania/imunologia
Leishmaniose Cutânea/patologia
Fator de Necrose Tumoral alfa/metabolismo
Adolescente
Adulto
Idoso
Feminino
Humanos
Leishmaniose Cutânea/metabolismo
Meia-Idade
Masculino
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