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LESION SIZE CORRELATES WITH LEISHMANIA ANTIGEN-STIMULATED TNF-LEVELS IN HUMAN CUTANEOUS LEISHMANIASIS
Oliveira, Fabiano et al. | Date Issued: 2011
Author
Oliveira, Fabiano
Bafica, Andre Luiz Barbosa
Rosato, Andréa Bomura
Favali, Cecilia Beatriz Fiuza
Costa, Jackson Mauricio Lopes
Cafe, Virginia
Barral Netto, Manoel
Barral, Aldina Maria Prado
Affilliation
National Institutes of Health. Laboratory of Malaria and Vector Research. Rockville, MD
Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Florianopolis, SC, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil
Universidade de Brasília. Instituto de Ciencias Biologicas. Departamento de Biologia Celular. Brasilia, DF, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imuno-regulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia - iii - INCT. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia - iii - INCT. Salvador, BA, Brasil
Abstract
Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time ( P = 0.029), age ( P = 0.002), and TNF levels ( P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions
DeCS
Antígenos de Protozoários/imunologia
Leishmania/imunologia
Leishmaniose Cutânea/patologia
Fator de Necrose Tumoral alfa/metabolismo
Adolescente
Adulto
Idoso
Feminino
Humanos
Leishmaniose Cutânea/metabolismo
Meia-Idade
Masculino
 
Publisher
The American Society of Tropical Medicine and Hygiene
Citation
OLIVEIRA, F. et al. Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 70-73, 2011
DOI
10.4269/ajtmh.2011.10-0680
ISSN
1476-1645