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https://www.arca.fiocruz.br/handle/icict/7234
GENETIC POPULATION STRUCTURE OF CERCARIAE FROM AN URBAN FOCI OF SCHISTOSOMA MANSONI, BRAZIL
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Municipal Secretariat of Health. Center for Control of Zoonoses. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Biomedical Research Building. Cleveland, OH
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Biomedical Research Building. Cleveland, OH
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Municipal Secretariat of Health. Center for Control of Zoonoses. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Biomedical Research Building. Cleveland, OH
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Center for Global Health and Diseases. Case Western Reserve University. Biomedical Research Building. Cleveland, OH
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Rapid urbanization in Brazil has meant that many persons from rural areas where Schistosoma mansoni
is endemic have migrated to cities. Discovery of a focus of active transmission in the city of Salvador prompted a citywide
survey for active and potential transmission sites. Cercariae shed from infected snails collected from four locations were
used to determine how these samples were related and if they were representative of the parasite population infecting
humans. Each cercarial collection was greatly differentiated from the others, and diversity was significantly lower when
compared with eggs from natural human infections in one site. Egg samples collected 7 years apart in one neighborhood
showed little differentiation (Jost’s D = 0.01–0.03). Given the clonal nature of parasite reproduction in the snail host and
the short-term acquisition of parasites, cercariae from collections at one time point are unlikely to be representative of
the diversity in the human population.
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