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https://www.arca.fiocruz.br/handle/icict/7143
PROTOZOAN ENCOUNTERS WITH TOLL-LIKE RECEPTOR SIGNALLING PATHWAYS: IMPLICATIONS FOR HOST PARASITISM
Host-Parasite Interactions
Protozoan Infections/immunology
Signal Transduction
Toll-Like Receptors/physiology
Affilliation
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil/ Oswaldo Cruz Foundation. Rachou Research Center. Laboratory of Immunopathology. Belo Horizonte, MG, Brazil/ University of Massachusetts Medical School. Infectious Diseases and Immunology. Worcester. Massachusetts, USA
Cornell University. College of Veterinary Medicine. Department of Microbiology and Immunology. Ithaca, NY, USA.
Cornell University. College of Veterinary Medicine. Department of Microbiology and Immunology. Ithaca, NY, USA.
Abstract
Toll-like receptors (TLRs) have emerged as a major receptor family involved in non-self recognition. They have a vital role in triggering innate immunity and orchestrate the acquired immune response during bacterial and viral infection. However, the role of TLRs during infection with protozoan pathogens is less clear. Nevertheless, our understanding of how these parasitic microorganisms engage the host TLR signalling system has now entered a phase of rapid expansion. This Review describes recent insights into how parasitic protozoans are sensed by TLR molecules, and how the TLR system itself can be targeted by these microbial pathogens for their own survival
Keywords
Eukaryota/immunologyHost-Parasite Interactions
Protozoan Infections/immunology
Signal Transduction
Toll-Like Receptors/physiology
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