Comparative immunology of human and animal models of hookworm infection

George Washington University. Department of Microbiology, Immunology and Tropical Medicine. Washington DC, USA/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil
George Washington University. Department of Microbiology, Immunology and Tropical Medicine. Washington DC, USA/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil
George Washington University. Department of Microbiology, Immunology and Tropical Medicine. Washington DC, USA/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil
George Washington University. Department of Microbiology, Immunology and Tropical Medicine. Washington DC, USA

Abstract

Hookworm infection is a major cause of disease burden for animals and humans. Over the past years, the use of animal models in hookworm infections has been driven by the search of new anthelminthic therapies and, especially, vaccine devel-opment. These studies also contributed to the advance of knowledge on immunity to hookworms, offering new insights to understand the nature of this parasitic infection. In this article, we will summarize the essential features of the immune response in the two major animal models of hookworm infec-tions (dog and hamster) and then consider its implication for the human immune response

Keywords

animal models
hookworm
human
immunology

Publisher

Blackwell Scientific Publications

Citation

FUJIWARA, Ricardo Toshio et al. Comparative immunology of human and animal models of hookworm infection. Parasite Immunol. 2006 Jul;28(7):285-93.

ISSN

0141-9838

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7136

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