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https://www.arca.fiocruz.br/handle/icict/6772
STRUCTURAL STUDIES AND CYTOTOXIC ACTIVITY OF N(4)-PHENYL-2-BENZOYLPYRIDINE THIOSEMICARBAZONE SN(IV) COMPLEXES.
Author
Affilliation
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Abstract
Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl3].CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2].H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells.
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