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SEX-RELATED DIFFERENCES IN INFLAMMATORY AND IMMUNE ACTIVATION MARKERS BEFORE AND AFTER COMBINED ANTIRETROVIRAL THERAPY INITIATION
Mathad, Jyoti S. et al. | Fecha del documento: 2016
Autor
Mathad, Jyoti S.
Gupte, Nikhil
Balagopal, Ashwin
Asmuth, David M.
Hakim, James
Santos, Breno
Riviere, Cynthia
Hosseinipour, Mina
Sugandhavesa, Patcharaphan
Infante, Rosa
Pillay, Sandy
Cardoso, Sandra Wagner
Mwelase, Noluthando
Pawar, Jyoti
Berendes, Sima
Kumarasamy, Nagalingeswaran
Andrade, Bruno de Bezerril
Campbell, Thomas B.
Currier, Judith S.
Cohn, Susan E.
Gupta, Amita
Afiliación
Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. New York, NY, USA.
Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Division of Infectious Diseases. Baltimore, USA.
Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India.
University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA.
University of Zimbabwe College of Health Sciences. Harare, Zimbabwe.
Hospital Nossa Senhora de Conceição. Divisão de Doenças Infecciosas. Porto Alegre, RS, Brasil.
Les Centres GHESKIO. Port-Au-Prince, Haiti.
University of North Carolina-Lilongwe. Department of Medicine. Lilongwe, Malawi.
Research Institute for Health Sciences. Chiang Mai, Thailand.
IMPACTA Peru. San Miguel, Peru.
Durban University of Technology. Durban International Clinical Research Site. Durban, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
University of Witwatersrand. Department of Medicine. Johannesburg, South Africa.
National AIDS Research Institute. Pune, India.
Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi.
YRGCARE Medical Centre. Chennai, India.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Departamento de Medicina de Investigações. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil.
University of Colorado-Denver. Aurora, CO, USA.
David Geffen School of Medicine at University of California Los Angeles. Los Angeles, USA.
Northwestern University Feinberg School of Medicine. Division of Infectious Diseases. Chicago, USA.
Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Division of Infectious Diseases. Baltimore, USA.
Resumen en ingles
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (VL). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers (IFN-γ, TNF-α, IL-6, IL-18, IP-10, CRP, LPS, sCD14) were measured at weeks 0, 24, and 48 post-cART in a random subcohort (n=215) who achieved virologic suppression in ACTG A5175 (PEARLS). Association between sex and changes in markers post-cART was examined using random effects models. Average marker differences and 95%CI were estimated using multivariable models. Results: At baseline, women had lower median log10VL (4.93 vs 5.18 copies/mL, p=0.01), CRP (2.32 vs 4.62 mg/L, p=0.01), detectable LPS (39% vs 55%, p=0.04), and sCD14 (1.9 vs 2.3 mcg/mL, p=0.06) versus men. By week 48, women had higher IFN-γ (22.4 vs 14.9 pg/mL, p=0.05), TNF-α (11.5 vs 9.5 pg/mL, p=0.02), and CD4 (373 vs 323 cells/mm3 , p=0.02). In multivariate analysis, women had greater increases in CD4 and TNF-α but less of a decrease in CRP and sCD14 compared to men. Conclusions: With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality.
Palabras clave en portugues
HIV
Inflamação
Ativação imunológica
Sexo
Mulheres
Tratamento antirretroviral
 
Palabras clave en ingles
HIV
Inflammation
Immune activation
Sex
Women
Antiretroviral treatment
 
Editor
Lippincott Williams & Wilkins
Documentos relacionados
https://www.arca.fiocruz.br/handle/icict/17845
Referencia
MATHAD, Jyoti S. et al. Sex-related Differences in Inflammatory and Immune Activation Markers before and after combined Antiretroviral Therapy Initiation. Journal of Acquired Immune Deficiency Syndromes, v. 73, n. 2, p. 1-13, Oct. 2016.
DOI
10.1097/QAI.0000000000001095
ISSN
1525-4135
Notas
The New Work Concept Sheet 319 and AIDS Clinical Trials Group A5175 (PEARLS) study teams.