Soil-transmitted helminthiases (STH) are infections transmitted by eggs of intestinal worms in human feces, which in turn contaminate the grounds in areas lacking proper sewage treatment. STH, including hookworm, roundworm, and whipworm, remain among the most common infectious diseases worldwide. In Brazil, STH still exist, although their incidence has decreased due to improved sanitary conditions. Studies on intestinal parasites in Brazil are limited, isolated, and relatively rare, and generally reflect the situation in small towns. In the present study, geographic information system (GIS) was used to describe the spatial distribution profile of STH cases among 20,076 individuals attending the Laboratory of Faculty of Pharmacy (UFBA, Bahia) from Jan 2012 to Aug 2022. Of 1,592 cases, 1,430 (89.8%) were identified in 111 (62.5%) of Salvador's districts, for a total of 0.70 cases per 1,000 inhabitants. The remaining cases were from the Salvador metropolitan area (n = 13; 0.8%) or had missing data (n = 149; 9.4%). The most common parasite was roundworm (45.2%), followed by whipworm (32.5%) and hookworm (30.8%). Multiple infections were observed in 121 individuals (7.6%). Surprisingly, the model-based maps showed the highest concentrations of STH cases per 1,000 inhabitants in high-income areas, such as Ondina (123.25), Barra (16.82), and Canela (9.18). These areas are located in two river basins contaminated by urban runoff and stormwater. Although they are encapsulated and located in areas with a high number of connections to the public wastewater collection network, solid waste from residential and commercial areas, gas stations, laboratories, hospitals, and a cemetery is discharged into the riverbed. Our results can guide future health initiatives through intensive integrated control measures in areas with high numbers of STH cases.