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- INI - Artigos de Periódicos [3460]
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HOW CARDIAC FIBROSIS ASSESSED VIA T1 MAPPING IS ASSOCIATED WITH LIVER FIBROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Cardiovascular Disease
Fibrosis
Myocardial Extracellular Volume
Magnetic Resonance
Autor
Terzi, Flavia Vernin de Oliveira
Camargo, Gabriel Cordeiro
Parente, Daniella Braz
Pittella, Ana Maria
Silva-Junior, Gilberto
Novaes, Gabrielle Gonçalves de
Oliveira Neto, Jaime Araújo
Barroso, Julia Machado
Pinheiro, Martha Valéria Tavares
Brito, Adriana Soares Xavier de
Oliveira, Renée Sarmento de
Rodrigues, Rosana Souza
Perez, Renata de Mello
Sousa, Andréa Silvestre de
Moll-Bernardes, Renata Junqueira
Camargo, Gabriel Cordeiro
Parente, Daniella Braz
Pittella, Ana Maria
Silva-Junior, Gilberto
Novaes, Gabrielle Gonçalves de
Oliveira Neto, Jaime Araújo
Barroso, Julia Machado
Pinheiro, Martha Valéria Tavares
Brito, Adriana Soares Xavier de
Oliveira, Renée Sarmento de
Rodrigues, Rosana Souza
Perez, Renata de Mello
Sousa, Andréa Silvestre de
Moll-Bernardes, Renata Junqueira
Afiliación
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Resumen en ingles
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality, but the correlation between these markers in patients with NAFLD has not been well studied. Our main objective was to determine the degree of myocardial fibrosis in patients with NAFLD and its correlation with the severity of liver fibrosis. (2) Methods: In this cross-sectional study, patients with NAFLD were allocated to two groups according to the stage of liver fibrosis assessed using MRI: no or mild fibrosis (F0-F1) and significant fibrosis (F2-F4). Framingham risk scores were calculated to evaluate cardiovascular risk factors, and patients underwent multiparametric cardiac and abdominal MRIs. (3) Results: The sample comprised 44 patients (28 with no or mild liver fibrosis and 16 with significant liver fibrosis). The mean age was 57.9 ± 12 years, and 41% were men. Most patients had high cardiac risk factors and carotid disease. Relative to patients with no or mild liver fibrosis, those with significant fibrosis had a higher median calcium score (p = 0.05) and increased myocardial extracellular volume (ECV; p = 0.02). Liver fibrosis correlated with cardiac fibrosis, represented by the ECV (r = 0.49, p < 0.001). The myocardial ECV differentiated patients with and without significant liver fibrosis (AUC = 0.78). (4) Conclusion: This study showed that diffuse myocardial fibrosis is associated with liver fibrosis in patients with NAFLD.
Palabras clave en ingles
Nonalcoholic Fatty Liver DiseaseCardiovascular Disease
Fibrosis
Myocardial Extracellular Volume
Magnetic Resonance
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