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MARÉ COHORT-PROFILE: A PROSPECTIVE COHORT STUDY BASED IN A SOCIALLY VULNERABLE COMMUNITY DURING THE COVID-19 PANDEMIC IN RIO DE JANEIRO, BRAZIL
Batista-da-Silva, Amanda A. et al. | Fecha del documento: 2023
Autor
Batista-da-Silva, Amanda A.
Ranzani, Olivia T.
Paulo, Daniela M. de
Braunstein, Mariana L.
Bozza, Helena R.
Fischer, Ronald
Ramos, Grazielle V.
Dias, Carolina M. C.
Silva, Everton P. da
Arouca, Luna E.
Bastos, Leonardo L. S.
Ranzani, Otavio T.
Hamacher, Silvio
Bozza, Fernando A.
Afiliación
Pontifical Catholic University of Rio de Janeiro. Department of Industrial Engineering. Rio de Janeiro, RJ, Brazil / Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
Pontifical Catholic University of Rio de Janeiro. Department of Industrial Engineering. Rio de Janeiro, RJ, Brazil / Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
Pontifical Catholic University of Rio de Janeiro. Department of Industrial Engineering. Rio de Janeiro, RJ, Brazil / Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Institute of Economics. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Victoria University of Wellington. School of Psychology. Wellington, New Zealand.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Associação Redes de Desenvolvimento da Maré. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Graduate Program on Sociology and Anthropology. Rio de Janeiro, RJ, Brazil.
Associação Redes de Desenvolvimento da Maré. Rio de Janeiro, RJ, Brasil.
Associação Redes de Desenvolvimento da Maré. Rio de Janeiro, RJ, Brasil.
Pontifical Catholic University of Rio de Janeiro. Department of Industrial Engineering. Rio de Janeiro, RJ, Brazil / Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
University of São Paulo. Faculty of Medicine. Faculty of Medicine. Pulmonary Division. Heart Institute. São Paulo, SP, Brazil / Barcelona Institute for Global Health. ISGlobal. Universitat Pompeu Fabra. CIBER Epidemiología y Salud Pública. Barcelona, Spain.
Pontifical Catholic University of Rio de Janeiro. Department of Industrial Engineering. Rio de Janeiro, RJ, Brazil / Pontifical Catholic University of Rio de Janeiro. Tecgraf Institute. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil.
Resumen en ingles
Background: Socially vulnerable populations were vastly affected by the COVID-19 pandemic. The pandemic significantly impacted Brazil, pressuring its healthcare system for several months, with high mortality rates, even among the youngest population. Cohort studies combining disease surveillance are essential for understanding virus circulation in the community, surrogates of protection, vaccine effectiveness, and demand for health resources. Methods: Here, we present the protocol for a community-based prospective cohort study in the largest complex of favelas (slums) in Rio de Janeiro, Brazil (Complexo da Maré). The study participants are residents initially recruited during a massive vaccination campaign in the community. Five waves of data collection at approximately six-month intervals were planned. The first two waves have been completed at the time of writing this study protocol, and the third is underway. The protocol comprises interviews, blood sampling, and records linkage with secondary data to enrich the profiles of cohort participants and community information. We will describe COVID-19 seroprevalence, socio-demographic characteristics, and the burden of COVID-19, followed by estimating the association of socioeconomic factors and the burden of disease with seroprevalence. Discussion: The primary aims of the study are to assess COVID-19 clinical, epidemiological and genomic profiles and outcomes in residents from Maré, including vaccine effectiveness, surrogates of immune protection, virus transmission in households, and the overall burden of the pandemic.
Palabras clave en ingles
Cohort
COVID-19
Serosurvey
LMIC
Community
Vaccine
Household
 
Editor
Bill and Melinda Gates Foundation
Referencia
BATISTA-DA-SILVA, Amanda A. et al. Maré cohort-profile: a prospective cohort study based in a socially vulnerable community during the COVID-19 pandemic in Rio de Janeiro, Brazil. Gates Open Research, v. 7, n. 22, p. 1-14, Sep. 2023.
DOI
10.12688/gatesopenres.14035.1
ISSN
2572-4754