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https://www.arca.fiocruz.br/handle/icict/6274
SCHISTOSOMAL GLOMERULOPATHY AND CHANGES IN THE DISTRIBUTION OF HISTOLOGICAL PATTERNS OF GLOMERULAR DISEASES IN BAHIA, BRAZIL
Schistosoma mansoni
Schistosoma japonicum
Mesangiocapillary glomerulonephritis
Kidney diseases
Focal segmental glomerulosclerosis
Membranoproliferativa/parasitologia
Glomerulosclerose Segmentar e Focal/parasitologia
Esquistossomose Japônica/complicações
Esquistossomose mansoni/complicações
Biópsia
Glomerulonefrite Membranoproliferativa/imunologia
Glomerulonefrite Membranoproliferativa/patologia
Glomerulosclerose Segmentar e Focal/imunologia
Glomerulosclerose Segmentar e Focal/patologia
Esquistossomose Japônica/imunologia
Esquistossomose Japônica/patologia
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/patologia
Humanos
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Escola Bahiana de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Escola Bahiana de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Abstract
Distinct patterns of glomerular lesions, including membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis, are associated with infection by Schistosoma mansoni or Schistosoma japonicum. Evidence suggests that immune complex deposition is the main mechanism underlying the different forms of schistosomal glomerulonephritis and that immune complex deposition may be intensified by portal hypertension. The relationship between focal segmental glomerulosclerosis and schistosomiasis remains poorly understood. A clinicopathologic classification of schistosomal glomerulopathies was proposed in 1992 by the African Association of Nephrology. In Brazil, mass treatment with oral medications has led to a decrease in the occurrence of schistosomal glomerulopathy. In a survey of renal biopsies performed in Salvador, Brazil, from 2003-2009, only 24 (4 percent) patients were identified as positive for S. mansoni infection. Among these patients, only one had the hepatosplenic form of the disease. Focal segmental glomerulosclerosis was found in seven patients and membranoproliferative glomerulonephritis was found in four patients. Although retrospective studies on the prevalence of renal diseases based on kidney biopsies may be influenced by many patient selection biases, a change in the distribution of glomerulopathies associated with nephrotic syndrome was observed along with a decline in the occurrence of severe forms of schistosomiasis.
Keywords
SchistosomiasisSchistosoma mansoni
Schistosoma japonicum
Mesangiocapillary glomerulonephritis
Kidney diseases
Focal segmental glomerulosclerosis
DeCS
GlomerulonefriteMembranoproliferativa/parasitologia
Glomerulosclerose Segmentar e Focal/parasitologia
Esquistossomose Japônica/complicações
Esquistossomose mansoni/complicações
Biópsia
Glomerulonefrite Membranoproliferativa/imunologia
Glomerulonefrite Membranoproliferativa/patologia
Glomerulosclerose Segmentar e Focal/imunologia
Glomerulosclerose Segmentar e Focal/patologia
Esquistossomose Japônica/imunologia
Esquistossomose Japônica/patologia
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/patologia
Humanos
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