Please use this identifier to cite or link to this item:
NEONATAL MORTALITY RISK FOR VULNERABLE NEWBORN TYPES IN 15 COUNTRIES USING 125.5 MILLION NATIONWIDE BIRTH OUTCOME RECORDS, 2000–2020
Nascimento prematuro
Tamanho para idade gestacional
Recém-nascido vulnerável
Nascimento Prematuro
Recém-Nascido Pequeno para a Idade Gestacional
Author
Affilliation
Abstract
Objective: To compare neonatal mortality associated with six novel vulnerable newborn types in 125.5 million live births across 15 countries, 2000-2020. Design: Population-based, multi-country study. Setting: National data systems in 15 middle- and high-income countries. Methods: We used individual-level data sets identified for the Vulnerable Newborn Measurement Collaboration. We examined the contribution to neonatal mortality of six newborn types combining gestational age (preterm [PT] versus term [T]) and size-for-gestational age (small [SGA], <10th centile, appropriate [AGA], 10th-90th centile or large [LGA], >90th centile) according to INTERGROWTH-21st newborn standards. Newborn babies with PT or SGA were defined as small and T + LGA was considered as large. We calculated risk ratios (RRs) and population attributable risks (PAR%) for the six newborn types. Main outcome measures: Mortality of six newborn types. Results: Of 125.5 million live births analysed, risk ratios were highest among PT + SGA (median 67.2, interquartile range [IQR] 45.6-73.9), PT + AGA (median 34.3, IQR 23.9-37.5) and PT + LGA (median 28.3, IQR 18.4-32.3). At the population level, PT + AGA was the greatest contributor to newborn mortality (median PAR% 53.7, IQR 44.5-54.9). Mortality risk was highest among newborns born before 28 weeks (median RR 279.5, IQR 234.2-388.5) compared with babies born between 37 and 42 completed weeks or with a birthweight less than 1000 g (median RR 282.8, IQR 194.7-342.8) compared with those between 2500 g and 4000 g as a reference group. Conclusion: Preterm newborn types were the most vulnerable, and associated with the highest mortality, particularly with co-existence of preterm and SGA. As PT + AGA is more prevalent, it is responsible for the greatest burden of neonatal deaths at population level.
Keywords in Portuguese
Mortalidade neonatalNascimento prematuro
Tamanho para idade gestacional
Recém-nascido vulnerável
DeCS
Mortalidade Neonatal PrecoceNascimento Prematuro
Recém-Nascido Pequeno para a Idade Gestacional
Share