Early Detection of the Recombinant SARS-CoV-2 XAN Variant in Bulgaria: Initial Genomic Insights into Yet Another Piece of the Growing Puzzle of Recombinant Clades

National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte,MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. Università Campus Bio-Medico di Roma. Rome, Italy
Burnett School of Biomedical Sciences. University of Central Florida. Orlando, FL, USA
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
Department of Biomedical Sciences. University of Sassari. Sassari, Italy
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
Unit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, Italy

Abstract

The first recombinant SARS-CoV-2 variants were identified in 2022, causing public health concerns. The importance of recombinant variants has increased especially since the WHO designated the recombinant variant XBB and its lineages as subvariants that require monitoring on 20 November 2022. In this study, we provide the first insights into the new SARS-CoV-2 variant named XAN, a recombinant composed of Omicron sub-lineages BA.2 and BA.5. To our knowledge, this is the first report on the recombinant SARS-CoV-2 XAN variant identified in Bulgaria.

Keywords

recombinant SARS-CoV-2
XAN
BA.5
BA.2
Omicron variant
coronavirus
molecular dating
phylogenomics
COVID-19 pandemic

Publisher

MDPI

Citation

ALEXIEV, Ivan et al. Early Detection of the Recombinant SARS-CoV-2 XAN Variant in Bulgaria: Initial Genomic Insights into Yet Another Piece of the Growing Puzzle of Recombinant Clades. Microorganisms, v. 11, n. 8, 2041, 2023; https://doi.org/10.3390/microorganisms11082041

ISSN

2076-2607

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/60641

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Open access

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