Background: Long COVID conditions in people who had severe COVID-19 illness can include a variety of health problems, directly impacting health related quality of life (QoL). We evaluated QoL and fatigue changes overtime after hospital discharge due to COVID-19 in participants from RECOVER-SUS BRASIL study. Methods: RECOVER-SUS aims to understand the dynamics and dimension of the sequelae in individuals who were discharged after COVID-19 hospitalization in Brazil. Participants from INI-FIOCRUZ site (Rio de Janeiro) were contacted per telephone calls 30 and 180 days after hospital discharge. We used ACTG SF-21 to assess QoL, which has 8 domains (scores from 0 [worst] and 100 [best]), and multidimensional questionnaire of fatigue (MFI-20), which has 5 domains (scores from 4 to 20; increased scores indicate more fatigue). We evaluated differences in mean change in QoL and fatigue between visits using generalized estimating equation methods. Results: Of 220 participants included, 83 (37.7%) were aged 60+ years at hospital admission (median age: 55; IQR:45-65), 125 (56.8%) were cisgender man, 98 (44.6%) black/mixed-black, 84 (39.4%) primary education or less, 97 (48.7%) low income (=USD500/month) and 167 (75.9%) at least one comorbidity HIV prevalence was 5% (N=11/220), 186 (85,3%) needed oxygen support. Considering QoL scores, general health perception decreased significantly between visits, while physical functioning and role functioning increased (Table 1). For fatigue, reduced activity scores decreased significantly between visits, meaning improvement in this MFI-20 domain. No difference between visits was observed for other QoL or fatigue domains.