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https://www.arca.fiocruz.br/handle/icict/60579
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ArtigoDireito Autoral
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- INI - Artigos de Periódicos [3498]
- IOC - Artigos de Periódicos [12791]
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DIVERSITY OF ANAL HPV AND NON-HPV SEXUALLY TRANSMITTED INFECTIONS AND CONCORDANCE WITH GENITAL INFECTIONS IN HIV-INFECTED AND HIV-UNINFECTED WOMEN IN THE TAPAJÓS REGION, AMAZON, BRAZIL
Autor(es)
Rodrigues, Luana Lorena Silva
Pilotto, José Henrique
Martinelli, Katrini Guidolini
Nicol, Alcina F.
Paula, Vanessa Salete de
Gheit, Tarik
Oliveira, Nathália Silva Carlos
Silva-de-Jesus, Carlos
Sahasrabuddhe, Vikrant V.
Silva, Diane M. da
Kast, W. Martin
Hardick, Justin
Gaydos, Charlotte A.
Morgado, Mariza Gonçalves
Pilotto, José Henrique
Martinelli, Katrini Guidolini
Nicol, Alcina F.
Paula, Vanessa Salete de
Gheit, Tarik
Oliveira, Nathália Silva Carlos
Silva-de-Jesus, Carlos
Sahasrabuddhe, Vikrant V.
Silva, Diane M. da
Kast, W. Martin
Hardick, Justin
Gaydos, Charlotte A.
Morgado, Mariza Gonçalves
Afiliação
Universidade Federal do Oeste do Pará. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Ciências da Saúde. Santarém, PA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
International Agency for Research on Cancer. Lyon, France.
Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
National Cancer Institute. Division of Cancer Prevention. Bethesda, USA.
University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA.
University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA / University of Southern California. Department of Molecular Microbiology and Immunology. Los Angeles, USA.
Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA.
Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
International Agency for Research on Cancer. Lyon, France.
Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
National Cancer Institute. Division of Cancer Prevention. Bethesda, USA.
University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA.
University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA / University of Southern California. Department of Molecular Microbiology and Immunology. Los Angeles, USA.
Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA.
Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajós region, Amazon, Brazil. A cross-sectional study was performed with 112 HIV-uninfected and 41 HIV-infected nonindigenous women. Anal and cervical scrapings were collected and analyzed for HPV, Chlamydia trachomatis (CT), Neisseria
gonorrheae (NG), Trichomonas vaginalis (TV), Mycoplasma genitalium (MG), and Human alphaherpesvirus 2 (HSV-2). The Kappa test evaluated the concordance between anal and genital infections. The overall prevalence of anal HPV infection was 31.3% in HIV-uninfected and 97.6% in HIV-infected women. The most frequent anal high-risk HPV (hrHPV) types were HPV18 and HPV16 in HIV-uninfected women and HPV51, HPV59, HPV31, and HPV58 in HIV-infected women. Anal HPV75 Betapapillomavirus was also identified. Anal non-HPV STIs were identified in 13.0% of all participants. The concordance analysis was fair for CT, MG, and HSV-2, almost perfect agreement for NG, moderate for HPV, and variable for the most frequent anal hrHPV types. Thus, a high prevalence of anal HPV infection with moderate and fair concordance between anal and genital HPV and non-HPV STIs was observed in our study.
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