Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)

Infectious Diseases Service. Hospital Clinic-IDIBAPS. University of Barcelona. Villarroel, Barcelona, Spain / CIBERINFEC. Instituto de Salud Carlos III. Madrid, Spain.
Infectious Diseases Service. Hospital Clinic-IDIBAPS. University of Barcelona. Villarroel, Barcelona, Spain.
Department of Precision Medicine. University of Campania 'L. Vanvitelli'. Monaldi Hospital. Naples, Italy.
Infectious Diseases and ICU. Pontchaillou University Hospital. Rennes, France.
Department of Infectious Diseases. Institute of Biomedicine. University of Gothenburg. Gothenburg, Sweden.
Centre of Cardiovascular Surgery and Transplantation. Brno, Czech Republic / Medical Faculty. Masaryk University. Brno, Czech Republic.
Mater Misericordiae University Hospital. University College Dublin. Dublin, Ireland.
Mater Misericordiae University Hospital. University College Dublin. Dublin, Ireland.
Duke University School of Medicine. Durham, NC, USA.
Department of Infectious Diseases and Tropical Medicine and Inserm CIC-1424. University of Lorraine Medical Center at Nancy. University of Lorraine, Nancy. France.
Infectious Diseases Service. Hospital Clinic-IDIBAPS. University of Barcelona. Villarroel, Barcelona, Spain.
Infectious Diseases Service. Hospital Clinic-IDIBAPS. University of Barcelona. Villarroel, Barcelona, Spain.
Biostatistics Department. Faculty of Biology. University of Barcelona, Barcelona. Spain.
Infectious Diseases Service. Hospital Clinic-IDIBAPS. University of Barcelona. Villarroel, Barcelona, Spain / CIBERINFEC. Instituto de Salud Carlos III. Madrid, Spain.

Resumo em Inglês

Introduction: Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide. Methods: The study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century. Results: IE cases from 13 European countries were included. Two periods were considered: 2000-2006 and 2008-2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern-Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 63.7 (49-74) years and 69.4% were males. Native valve IE (NVE), prosthetic valve IE (PVE), and device-related IE were diagnosed in 68.3%, 23.9%, and 7.8% of cases, respectively; 52% underwent surgery and 19.3% died during hospitalization. NVE was more prevalent in NCE, whereas device-related IE was more frequent in SE. Higher age, acute presentation, hemodialysis, cancer, and diabetes mellitus all were more prevalent in the second period. NVE decreased and PVE and device-related IE both increased in the second period. Surgical treatment also increased from 48.7% to 58.4% (p < 0.01). In-hospital and 6-month mortality rates were comparable between regions and significantly decreased in the second period. Conclusions: Despite an increased complexity of IE cases, prognosis improved in recent years with a significant decrease in 6-month mortality. Outcome did not differ according to the European region (SE versus NCE).

Palavras-chave em inglês

Cardiac surgery
Epidemiology
Europe
Infective endocarditis
Mortality

Editor

Springer Healthcare

Referência

AMBROSIONI, Juan et al. Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012). Infectious Diseases and Therapy, v. 4, p. 1083-1101, Apr. 2023.

DOI

10.1007/s40121-023-00763-8

ISSN

2193-8229

Notas

International Collaboration for Endocarditis (ICE) Investigators: Cristiane da Cruz Lamas - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.
Collaborators: International Collaboration for Endocarditis (ICE) Investigators: Liliana Clara, Marisa Sanchez, José Casabé, Claudia Cortes, Francisco Nacinovich, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, Javier Altclas, Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Lito Papanicolas, Tony Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P Feneley, John Harkness, Phillip Jones, Suzanne Ryan, Phillip Jones, Suzanne Ryan, Phillip Jones, Jeffrey Post, Porl Reinbott, Suzanne Ryan, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Claudio Querido Fortes, Auristela de Oliveira Ramos, Clara Weksler, Giovanna Ferraiuoli, Wilma Golebiovski, Cristiane Lamas, James A Karlowsky, Yoav Keynan, Andrew M Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, M Cereceda, Alberto Fica, Rodrigo Montagna Mella, Ricardo Fernandez, Liliana Franco, Javier Gonzalez, Astrid Natalia Jaramillo, Bruno Barsic, Suzana Bukovski, Vladimir Krajinovic, Ana Pangercic, Igor Rudez, Josip Vincelj, Tomas Freiberger, Jiri Pol, Barbora Zaloudikova, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Dina Osama, Hussien Rizk, Neijla Aissa, Corentine Alauzet, Francois Alla, Catherine Campagnac, Thanh Doco-Lecompte, Christine Selton-Suty, Jean-Paul Casalta, Pierre-Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, Francois Delahaye, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Erwan Flecher, Christian Michelet, Matthieu Revest, Pierre Tattevin, Florent Chevalier, Antoine Jeu, Jean Paul Rémadi, Dan Rusinaru, Christophe Tribouilloy, Yvette Bernard, Catherine Chirouze, Bruno Hoen, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Christoph Naber, Carl Neuerburg, Sophia Athanasia, Ioannis Deliolanis, Helen Giamarellou, Tsaganos Thomas, Efthymia Giannitsioti, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Elena Mylona, Olga Paniara, Konstantinos Papanikolaou, John Pyros, Athanasios Skoutelis, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Margaret M Hannan, John P Hurley, Maor Wanounou, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Ethan Rubinstein, Jacob Strahilevitz, Emanuele Durante-Mangoni, Domenico Iossa, Serena Orlando, Maria Paola Ursi, Pia Clara Pafundi, Fabiana D'Amico, Mariano Bernardo, Susanna Cuccurullo, Giovanni Dialetto, Franco Enrico Covino, Sabrina Manduca, Alessandro Della Corte, Marisa De Feo, Marie Françoise Tripodi, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Zeina Kanafani, Souha S Kanj, Ahmad Sharif-Yakan, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T M van der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David R Murdoch, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O M Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Yee-Yun Liew, Ru-San Tan, Tatjana Lejko-Zupanc, Mateja Logar, Manica Mueller-Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manel Almela, Juan Ambrosioni, Manuel Azqueta, Merce Brunet, Pedro Castro, Elisa De Lazzari, Carlos Falces, David Fuster, Guillermina Fita, Cristina Garcia-de-la-Maria, Javier Garcia-Gonzalez, Jose M Gatell, Jaume Llopis, Francesc Marco, José M Miró, Asuncion Moreno, José Ortiz, Salvador Ninot, J Carlos Paré, Juan M Pericas, Eduard Quintana, Jose Ramirez, Irene Rovira, Elena Sandoval, Marta Sitges, Adrian Tellez, José M Tolosana, Barbara Vidal, Jordi Vila, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Emilio Bouza, Miguel Angel Garcia Fernández, Victor Gonzalez-Ramallo Mercedes Marín, Patricia Muñoz, Miguel Pedromingo, Jorge Roda, Marta Rodríguez-Créixems, Jorge Solis, Benito Almirante, Nuria Fernandez-Hidalgo, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg-Martin, Orathai Pachirat, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L Klein, Suzanne Bradley, Carol Kauffman, Roger Bedimo, Vivian H Chu, G Ralph Corey, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Vance G Fowler, Thomas Holland, Tahaniyat Lalani, Daniel Mudrick, Zaniab Samad, Daniel Sexton, Martin Stryjewski, Andrew Wang, Christopher W Woods, Stamatios Lerakis, Robert Cantey, Lisa Steed, Dannah Wray, Stuart A Dickerman, Hector Bonilla, Joseph DiPersio, Sara-Jane Salstrom, John Baddley, Mukesh Patel, Gail Peterson, Amy Stancoven, Donald Levine, Jonathan Riddle, Michael Rybak, Christopher H Cabell, Khaula Baloch, Vivian H Chu, G Ralph Corey, Christy C Dixon, Vance G Fowler, Tina Harding, Marian Jones-Richmond, Lawrence P Park, Bob Sanderford, Judy Stafford, Kevin Anstrom, Eugene Athan, Arnold S Bayer, Christopher H Cabell, Vivian H Chu, G Ralph Corey, Vance G Fowler, Bruno Hoen, A W Karchmer, José M Miró, David R Murdoch, Daniel J Sexton, Andrew Wang, Arnold S Bayer, Christopher H Cabell, Vivian Chu, G Ralph Corey, David T Durack, Susannah Eykyn, Vance G Fowler, Bruno Hoen, José M Miró, Phillipe Moreillon, Lars Olaison, Didier Raoult, Daniel J Sexton.

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/60242

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