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COMPARISON OF 68GA-DOTATOC AND 18F-FDG THORACIC LYMPH NODE AND PULMONARY LESION UPTAKE USING PET/CT IN POSTPRIMARY TUBERCULOSIS
Rosado-de-Castro, Paulo Henrique et al. | Date Issued: 2022
Author
Rosado-de-Castro, Paulo Henrique
Pereira-de-Carvalho, Thiago
Barreto, Miriam Menna
Kritski, Afranio Lineu
Souza, Rebecca de Oliveira
Almeida, Sergio Altino de
Rolla, Valeria Cavalcanti
Zin, Walter Araujo
Carvalho, Alysson Roncally Silva
Rodrigues, Rosana Souza
Affilliation
D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Petropolis School of Medicine/Arthur Sá Earp Neto Faculty. Department of Internal Medicine. Petropolis, RJ, Brazil.
Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Academic Tuberculosis Program. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Department of Statistical Methods. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Mycobacteria. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil / University of Porto. Faculty of Medicine. Department of Surgery and Physiology. Cardiovascular R&D Centre (UnIC). Porto, Portugal / Federal University of Rio de Janeiro. Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering. Biomedical Engineering Program. Laboratory of Pulmonary Engineering. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.
Abstract
Tuberculosis (TB) remains one of the world's leading infectious cause of morbidity and mortality. Positron emission tomography (PET) associated with computed tomography (CT) allows a structural and metabolic evaluation of TB lesions, being an excellent noninvasive alternative for understanding its pathogenesis. DOTATOC labeled with gallium-68 (68Ga-DOTATOC) can bind to somatostatin receptors present in activated macrophages and lymphocytes, cells with a fundamental role in TB pathogenesis. We describe 68Ga-DOTATOC uptake distribution and patterns in thoracic lymph nodes (LN) and pulmonary lesions (PL) in immunocompetent patients with active postprimary TB, analyze the relative LN/PL uptake, and compare this two tracer's uptake. High uptake of both radiotracers in PL and LN was demonstrated, with higher LN/PL ratio on 68Ga-DOTATOC (P < 0.05). Considering that LN in immunocompetent patients are poorly studied, 68Ga-DOTATOC can contribute to the understanding of the complex immunopathogenesis of TB.
Keywords
Tuberculosis
Computed tomography (CT)
Ga-DOTATOC
Thoracic Lymph Node
Pulmonary Lesion
 
Publisher
American Society of Tropical Medicine and Hygiene
Citation
ROSADO-DE-CASTRO, Paulo Henrique et al. Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis. The American Journal of Tropical Medicine and Hygiene, v. 106, n. 5, p. 1340-1344, Apr. 2022.
DOI
10.4269/ajtmh.21-0416
ISSN
0002-9637