Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/59649
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-12-31
Coleções
Metadata
Mostrar registro completo
EARLY AND LATE ACUTE LUNG INJURY AND THEIR ASSOCIATION WITH DISTAL ORGAN DAMAGE IN MURINE MALARIA
Lung mechanics
Histology
Respiratory-distress-syndrome
Cerebral malaria
Falciparum-malaria
Autor(es)
Afiliação
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
University of São Paulo. Faculty of Medicine. Department of Pathology. São Paulo, SP, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
University of São Paulo. Faculty of Medicine. Department of Pathology. São Paulo, SP, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Severe malaria is characterised by cerebral oedema, acute lung injury (ALI) and multiple organ dysfunctions, however, the mechanisms of lung and distal organ damage need to be better clarified. Ninety-six C57BL/6 mice were injected intraperitoneally with 5×10(6)Plasmodium berghei ANKA-infected erythrocytes or saline. At day 1, Plasmodium berghei infected mice presented greater number of areas with alveolar collapse, neutrophil infiltration and interstitial oedema associated with lung mechanics impairment, which was more severe at day 1 than day 5. Lung tumour necrosis factor-α and chemokine (C-X-C motif) ligand 1 levels were higher at day 5 compared to day 1. Lung damage occurred in parallel with distal organ injury at day 1; nevertheless, lung inflammation and the presence of malarial pigment in distal organs were more evident at day 5. In conclusion, ALI develops prior to the onset of cerebral malaria symptoms. Later during the course of infection, the established systemic inflammatory response increases distal organ damage.
Palavras-chave em inglês
CytokinesLung mechanics
Histology
Respiratory-distress-syndrome
Cerebral malaria
Falciparum-malaria
Compartilhar