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AUTOPHAGY IN PROTISTS AND THEIR HOSTS: WHEN, HOW AND WHY?
Romano, Patricia Silvia et al. | Data do documento: 2023
Autor(es)
Romano, Patricia Silvia
Akematsu, Takahiko
Besteiro, Sébastien
Bindschedler, Annina
Carruthers, Vern B.
Chahine, Zeinab
Coppens, Isabelle
Descoteaux, Albert
Duque, Thabata Lopes Alberto
He, Cynthia Y.
Heussler, Volker
Le Roch, Karine G.
Li, Feng-Jun
Menezes, Juliana Perrone Bezerra de
Menna- Barreto, Rubem Figueiredo Sadok
Mottram, Jeremy C.
Schmuckli-Maurer, Jacqueline
Turk, Boris
Veras, Patricia Sampaio Tavares
Salassa, Betiana Nebai
Vanrell, María Cristina
Afiliação
Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.
Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo, Japan.
LPHI, Univ Montpellier, CNRS, Montpellier, France.
Institute of Cell Biology.University of Bern. Baltzerstr, Bern, Switzerland.
Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA.
Department of Molecular Microbiology and Immunology. Johns Hopkins Malaria Research Institute. Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, USA.
Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada.
Autophagy Inflammation and Metabolism Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA / Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Autophagy Inflammation and Metabolism Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA / Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Department of Biological Sciences, National University of Singapore, Singapore.
Institute of Cell Biology.University of Bern. Baltzerstr, Bern, Switzerland.
Department of Biological Sciences, National University of Singapore, Singapore.
Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Laboratory of Host-Parasite Interaction and Epidemiology. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
York Biomedical Research Institute, Department of Biology, University of York, York, UK.
Department of Biochemistry and Molecular and Structural Biology. Jožef Stefan Institute. Ljubljana, Slovenian.
Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Laboratory of Host-Parasite Interaction and Epidemiology. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases. National Council for Scientific Research and Development, Brasil.
Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.
Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.
Resumo em Inglês
Pathogenic protists are a group of organisms responsible for causing a variety of human diseases including malaria, sleeping sickness, Chagas disease, leishmaniasis, and toxoplasmosis, among others. These diseases, which affect more than one billion people globally, mainly the poorest populations, are character ized by severe chronic stages and the lack of effective antiparasitic treatment. Parasitic protists display complex life-cycles and go through different cellular transformations in order to adapt to the different hosts they live in. Autophagy, a highly conserved cellular degradation process, has emerged as a key ism required for these differentiation processes, as well as other functions that are crucial to parasite fitness. In contrast to yeasts and mammals, protist autophagy is characterized by a modest number of conserved autophagy- related proteins (ATGs) that, even though, can drive the autophagosome mation and degradation. In addition, during their intracellular cycle, the action of these pathogens with the host autophagy system plays a crucial role resulting in a beneficial or harmful effect that is important for the outcome of the infection. In this review, we summarize the current state of knowledge on autophagy and other related mechanisms in pathogenic protists and their hosts. We sought to emphasize when, how, and why this process takes place, and the effects it may have on the parasitic cycle. A better understanding of the significance of autophagy for the protist life-cycle will potentially be helpful to design novel anti-parasitic strategies.
Palavras-chave
Autofagia
Protistas
Vida útil
Leishmania sp.
Plasmodium sp.
Toxoplasma gondii
Trypanosoma brucei
Trypanosoma cruzi
 
Palavras-chave em inglês
Autophagy
Protists
Life-cycle
Leishmania sp.
Plasmodium sp.
Tripanosoma brucei
Tripanosoma cruzi
Toxoplasma gondii
 
Editor
Taylor & Francis
Referência
ROMANO, Patricia Silva et al. Autophagy in protists and their hosts: When, how and why? Autophagy Reports, v. 2, n. 1, 2149211, p. 1-109, Mar. 2023.
DOI
10.1080/27694127.2022.2149211
ISSN
1554-8627