Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India

Department of Medical and Molecular Genetics. Indiana University School of Medicine. Indianapolis, USA.
Molecular Carcinogenesis Program, Research, Coordination National Cancer Institute. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Presidency. Vice-Presidency Research and Biological Collections. Rio de Janeiro, RJ, Brazil.
Department of Molecular Medicine and Haematology. School of Pathology. Faculty of Health Sciences. University of the Witwatersrand. Johannesburg, South Africa.
Spark Therapeutics. Philadelphia, USA.
Faculty of Medicine. University of Southampton. UK & KJ Somaiya. Super Speciality Hospital and Research Centre. Mumbai, India.
Department of Biological Sciences and Bioengineering. Indian Institute of Technology Kanpur. Kapur, India.

Resumo em Inglês

Gene and cell therapies for a variety of life-limiting illnesses are under investigation, and a small number of commercial products have successfully obtained regulatory approval. The cost of treatment is high, and clinical studies evaluating safety and efficacy are performed predominately in high-income countries. We reviewed the current status of gene and cell therapies in low- and middle-income countries and highlighted the need and current barriers to access. The state of product development in Brazil, South Africa, and India is discussed, including lessons learned from American Society of Gene and Cell Therapy (ASGCT)-sponsored virtual symposia in each of these countries.

Palavras-chave em inglês

Gene therapy access
Global challenges
Cell therapies
Cancer deaths
Gene therapy clinical

Editor

Medscape

Referência

CORNETTA, Kenneth et al. Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India. Molecular Therapy, v. 30, n. 6, p. 2122-2129, Jun. 2022.

DOI

10.1016/j.ymthe.2022.04.002

ISSN

1525-0016

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/57053

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