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INTERRELATIONSHIP BETWEEN ADIPOCYTES AND FIBROBLASTS DURING ACUTE DAMAGE TO THE SUBCUTANEOUS ADIPOSE TISSUE OF RATS: AN ULTRASTRUCTURAL STUDY.
Tecido Adiposo/patologia
Fibroblastos/ultraestrutura
Adipócitos/citologia
Animais
Diferenciação Celular
Feminino
Fibroblastos/citologia
Masculino
Fotomicrografia
Ratos
Ratos Wistar
Afiliación
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Resumen en ingles
Ultrastructural phenotypic transitional features were noted between adult adipocytes and fibroblasts in the subcutaneous adipose tissue of the dorsal pad of normal adult Wistar rats of both sexes, weighing 180-260 g, after acute injury either by the implantation of small (1.8 x 1 x 0.4 cm) perforated plastic boxes or by local heat application. Soon after the inflicted damage, fat-containing cells presented variable shapes. Early after damage, some of these cells were round, adipocyte-like, with numerous and large cytoplasmic fat droplets. A few days later, fat-containing cells became elongated, with the fat droplets in their cytoplasm becoming smaller and less numerous. The cells also showed a prominent active rough endoplasmic reticulum and newly formed collagenous matrix accumulated in the interstices. Although current views consider adult adipocytes to be terminal cells, the present findings, in their time sequence, strongly suggest the transformation of adipocytes into fibroblasts after acute injury to adipose tissue.
DeCS
Adipócitos/ultraestruturaTecido Adiposo/patologia
Fibroblastos/ultraestrutura
Adipócitos/citologia
Animais
Diferenciação Celular
Feminino
Fibroblastos/citologia
Masculino
Fotomicrografia
Ratos
Ratos Wistar
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