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ACTIVE SURVEILLANCE AND EARLY DETECTION OF COMMUNITY TRANSMISSION OF SARS‐COV‐2MU VARIANT (B.1.621) IN THE BRAZILIAN AMAZON
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Through active surveillance and contact tracing from outpatients, we aimed to identify
and characterize SARS‐CoV‐2 variants circulating in Porto Velho‐Rondônia, a city in the
Brazilian Amazon. As part of a prospective cohort, we gathered information from 2,506
individuals among COVID‐19 patients and household contacts. Epidemiological data,
nasopharyngeal swabs, and blood samples were collected from all participants.
Nasopharyngeal swabs were tested for antigen rapid diagnostic test and reverse
transcription‐polymerase chain reaction (RT‐PCR) followed by genomic sequencing. Blood
samples underwent ELISA testing for IgA, IgG, and IgM antibody levels. From 757
specimens sequenced, three were identified as Mu variant, none of the individuals
carrying this variant had a travel history in the previous 15 days before diagnosis. One
case was asymptomatic and two presented mild symptoms. Two infected individuals from
different households caring viruses with additional amino acid substitutions ORF7a P45L
and ORF1a T1055A compared to the Mu virus reference sequence. One patient
presented IgG levels. Our results highlight that genomic surveillance for SARS‐CoV‐2
variants can assist in detecting the emergency of SARS‐CoV‐2 variants in the community,
before its identification in other parts of the country.
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