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SARS‐COV‐2 AY.4.2 VARIANT CIRCULATING IN ITALY: GENOMIC PRELIMINARY INSIGHT
Author
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Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Public Health and Infectious Diseases, Policlinico Umberto I Università ‘Sapienza', Rome, Italy.
Diagnostic and Therapeutic Medicine Division, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome “La Sapienza”, Rome, Italy.
Unit of Virology, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio‐Medico of Rome, Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Clinical Laboratory Science, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Public Health and Infectious Diseases, Policlinico Umberto I Università ‘Sapienza', Rome, Italy.
Diagnostic and Therapeutic Medicine Division, University Campus Bio‐Medico of Rome, Rome, Italy.
Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome “La Sapienza”, Rome, Italy.
Unit of Virology, University Campus Bio‐Medico of Rome, Rome, Italy.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio‐Medico of Rome, Rome, Italy.
Abstract
The appearance of emerging variants of SARS‐CoV‐2 carrying mutations into the
spike protein has recently raised concern with respect to tracking their transmission
and mitigating the impact in the evolving pandemic across countries. AY.4.2, a
recently detected Delta variant sublineage, is considered a new variant under
investigation (VUI) as it carries specific genetic signatures present in the spike
protein, called Y145H and A222V. Here, using genomic epidemiology, we provide
the first preliminary insight regarding the circulation of this emerging VUI in Italy.
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