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CELL ADHESION PROTEINS IN THE CEREBROSPINAL FLUID OF NEONATES PRENATALLY EXPOSED TO ZIKA VIRUS: A CASE–CONTROL STUDY
Líquido cefalorraquidiano
Infecção congênita pelo vírus Zika
Espectrometria de massa
Microcefalia
Cerebrospinal fluid
Congenital Zika virus infection
Mass spectrometry
Microcephaly
Líquido Cefalorraquidiano
Infecção por Zika virus
Espectrometria de Massas
Microcefalia
Autor
Afiliación
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Fundação José Silveira. Laboratório do Líquido Cefalorraquidiano. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Section of Paediatric Infectious Diseases. Laboratory of Medical Immunology. Radboud Institute for Molecular Life Sciences. Radboud Centre for Infectious. Diseases, Radboud University Medical Center. Nijmegen, Netherlands.
Section of Paediatric Infectious Diseases. Laboratory of Medical Immunology. Radboud Institute for Molecular Life Sciences. Radboud Centre for Infectious. Diseases, Radboud University Medical Center. Nijmegen, Netherlands.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Universidade da Bahia. Federal Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina. Salvador, BA, Brasil.
Fundação José Silveira. Laboratório do Líquido Cefalorraquidiano. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Section of Paediatric Infectious Diseases. Laboratory of Medical Immunology. Radboud Institute for Molecular Life Sciences. Radboud Centre for Infectious. Diseases, Radboud University Medical Center. Nijmegen, Netherlands.
Section of Paediatric Infectious Diseases. Laboratory of Medical Immunology. Radboud Institute for Molecular Life Sciences. Radboud Centre for Infectious. Diseases, Radboud University Medical Center. Nijmegen, Netherlands.
Department of Neurology. Erasmus MC. Rotterdam, Netherlands.
Universidade da Bahia. Federal Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil.
Resumen en ingles
To compare cell adhesion molecules levels in cerebrospinal fluid (CSF) between Zika virus (ZIKV)-exposed neonates with/without microcephaly (cases) and controls, 16 neonates (cases), 8 (50%) with and 8 (50%) without microcephaly, who underwent lumbar puncture (LP) during the ZIKV epidemic (2015–2016) were included. All mothers reported ZIKV clinical symptoms during gestation, all neonates presented with congenital infection findings, and other congenital infections were ruled out. Fourteen control neonates underwent LP in the same laboratory (2017–2018). Five cell adhesion proteins were measured in the CSF using mass spectrometry. Neurexin-1 (3.50 [2.00–4.00] vs. 7.5 [5.00–10.25], P = 0.001), neurexin-3 (0.00 [0.00–0.00] vs. 3.00 [1.50–4.00], P = 0.001) and neural cell adhesion molecule 2 (NCAM2) (0.00 [0.00–0.75] vs. 1.00 [1.00–2.00], P = 0.001) were significantly lower in microcephalic and non-microcephalic cases than in controls. When these two sub-groups of prenatally ZIKA-exposed children were compared to controls separately, the same results were found. When cases with and without microcephaly were compared, no difference was found. Neurexin-3 (18.8% vs. 78.6%, P = 0.001) and NCAM2 (25.0% vs. 85.7%, P = 0.001) were less frequently found among the cases. A positive correlation was found between cephalic perimeter and levels of these two proteins. Neurexin-2 and neurexin-2b presented no significant differences. Levels of three cell adhesion proteins were significantly lower in CSF of neonates exposed to ZIKV before birth than in controls, irrespective of presence of congenital microcephaly. Moreover, the smaller the cephalic perimeter, the lower CSF cell adhesion protein levels. These findings suggest that low CSF levels of neurexin-1, neurexin-3 and NCAM2 may reflect the effects of ZIKV on foetal brain development.
Palabras clave en portugues
Proteína de adesão celularLíquido cefalorraquidiano
Infecção congênita pelo vírus Zika
Espectrometria de massa
Microcefalia
Palabras clave en ingles
Cell adhesion proteinCerebrospinal fluid
Congenital Zika virus infection
Mass spectrometry
Microcephaly
DeCS
Molécula 1 de adesão celularLíquido Cefalorraquidiano
Infecção por Zika virus
Espectrometria de Massas
Microcefalia
Editor
Wiley
Referencia
RAMOS, Clara L. et al. Cell adhesion proteins in the cerebrospinal fluid of neonates prenatally exposed to Zika virus: A case–control study. European Journal Neuroscience, v. 56, p. 1-11, 2022.DOI
10.1111/ejn.15851ISSN
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