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TRANSCRIPTIONAL ANALYSIS FOR TUBERCULOSIS IN PREGNANT WOMEN FROM THE PRACHITI STUDY
Mathad, Jyoti S et al. | Date Issued: 2022
Author
Mathad, Jyoti S
Queiroz, Artur T. L
Bhosale, Ramesh
Alexander, Mallika
Naik, Shilpa
Kulkarni, Vandana
Andrade, Bruno B
Gupta, Amita
Affilliation
Weill Cornell Medicine. Center for Global Health. NY, United States of America.
Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Byramjee Jeejeebhoy Government Medical College/Sassoon Government Hospital. Pune, India / Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College/Sassoon Government Hospital. Pune, India / Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit. Pune, India.
Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Baltimore, United States of America.
Abstract
A new tuberculosis diagnostic cartridge assay, which detects a 3-gene tuberculosis signature in whole blood, was not diagnostic in women with maternal tuberculosis disease in India (AUC = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).
Keywords in Portuguese
Tuberculose
Gravidez
assinatura de RNA
Transcrição
Imunologia
 
Keywords
Tuberculosis
Pregnancy
RNA signature
Transcriptomics
Immunology
 
DeCS
Tuberculose
Gravidez
Imunologia
 
Publisher
Oxford University Press
Citation
MATHAD, Jyoti S. et al. Transcriptional analysis for tuberculosis in pregnant women from the PRACHITi study. Clinical Infectious Diseases, p. 1-9, 2022.
DOI
10.1093/cid/ciac437
ISSN
1537-6591