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TWO NEW USNIC ACID DERIVATIVES FROM THE ENDOPHYTIC FUNGUS MYCOSPHAERELLA SP.
Eugenia bimarginata
Mycosphaerella sp
endophytic fungi
usnic acid derivatives
Author
Affilliation
Department of Sciences and Technologies. State University of Bahia Southwest. Jequié, BA, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Center for Technological Development in Health. Oswaldo Cruz Fundation. Rio de Janeiro, RJ, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Center for Technological Development in Health. Oswaldo Cruz Fundation. Rio de Janeiro, RJ, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Microbiology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Chemistry of Natural Bioactive Products. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Abstract
The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively
Keywords
Cryptococcus spEugenia bimarginata
Mycosphaerella sp
endophytic fungi
usnic acid derivatives
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