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https://www.arca.fiocruz.br/handle/icict/55116
CD4 T CELLS ARE RAPIDLY DEPLETED FROM TUBERCULOSIS GRANULOMAS FOLLOWING ACUTE SIV CO-INFECTION
Autor(es)
Foreman, Taylor W
Nelson, Christine E
Kauffman, Keith D
Lora, Nickiana E
Vinhaes, Caian L
Dorosky, Danielle E
Sakai, Shunsuke
Gomez, Felipe
Fleegle, Joel D
Parham, Melanie
Perera, Shehan R
Arlehamn, Cecilia S. Lindestam
Sette, Alessandro
Tuberculosis Imaging Program
Brenchley, Jason M
Queiroz, Artur T. L
Andrade, Bruno B
Kabat, Juraj
Via, Laura E
Barber, Daniel L
Nelson, Christine E
Kauffman, Keith D
Lora, Nickiana E
Vinhaes, Caian L
Dorosky, Danielle E
Sakai, Shunsuke
Gomez, Felipe
Fleegle, Joel D
Parham, Melanie
Perera, Shehan R
Arlehamn, Cecilia S. Lindestam
Sette, Alessandro
Tuberculosis Imaging Program
Brenchley, Jason M
Queiroz, Artur T. L
Andrade, Bruno B
Kabat, Juraj
Via, Laura E
Barber, Daniel L
Afiliação
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Axle Informatics. National Center for Advancing Translational Sciences. Bethesda, MD, USA.
Department of Electrical and Computer Engineering. The Ohio State University. Columbus, OH, USA.
Division of Vaccine Discovery. La Jolla Institute for Immunology. La Jolla, CA, USA.
Division of Vaccine Discovery. La Jolla Institute for Immunology. La Jolla, CA, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Barrier Immunity Section. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Biological Imaging Section. Research Technologies Branch. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA / Tuberculosis Research Section. Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA / Institute of Infectious Disease & Molecular Medicine and Division of Immunology. Department of Pathology. University of Cape Town. Observatory, Cape Town, South Africa.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Axle Informatics. National Center for Advancing Translational Sciences. Bethesda, MD, USA.
Department of Electrical and Computer Engineering. The Ohio State University. Columbus, OH, USA.
Division of Vaccine Discovery. La Jolla Institute for Immunology. La Jolla, CA, USA.
Division of Vaccine Discovery. La Jolla Institute for Immunology. La Jolla, CA, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Barrier Immunity Section. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Biological Imaging Section. Research Technologies Branch. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA / Tuberculosis Research Section. Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA / Institute of Infectious Disease & Molecular Medicine and Division of Immunology. Department of Pathology. University of Cape Town. Observatory, Cape Town, South Africa.
Tlymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA.
Resumo em Inglês
HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before it is evident in blood. Here, we use rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. Two weeks after SIV inoculation of Mtb-infected macaques, Mtb-specific CD4 T cells are dramatically depleted from granulomas, before CD4 T cell loss in blood, airways, and lymph nodes, or increases in bacterial loads or radiographic evidence of disease. Spatially, CD4 T cells are preferentially depleted from the granuloma core and cuff relative to B cell-rich regions. Moreover, live imaging of granuloma explants show that intralesional CD4 T cell motility is reduced after SIV co-infection. Thus, granuloma CD4 T cells may be decimated before many co-infected individuals experience the first symptoms of acute HIV infection.
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