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https://www.arca.fiocruz.br/handle/icict/55050
CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF DECOQUINATE: A REVIEW OF ITS PHARMACEUTICAL POTENTIAL AND FUTURE PERSPECTIVES
Antimicrobiano
Propriedades físico-químicas
Química Medicinal
Nanomedicamentos
Antimicrobial
Physicochemical properties
Medicinal chemistry
Nanomedicines
Afiliação
Universidade Federal da Bahia. Faculdade de Farmácia. Programa de Pós-Graduação em Farmácia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Farmácia. Programa de Pós-Graduação em Farmácia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Medicamentos. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Farmácia. Programa de Pós-Graduação em Farmácia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Medicamentos. Salvador, BA, Brasil.
Resumo em Inglês
Abstract: Decoquinate (DQ) is an antimicrobial agent commonly used as a feed additive for birds for human consumption. Its use as an additive is well established, but DQ has the potential for therapy as an antimicrobial drug for veterinary treatment and its optimized derivatives and/or formulations, mainly nanoformulations, have antimicrobial activity against pathogens that infect humans. However, DQ has a high partition coefficient and low solubility in aqueous fluids, and these biopharmaceutical properties have limited its use in humans. In this review, we highlight the antimicrobial activity and pharmacokinetic properties of DQ and highlight the solutions currently under investigation to overcome these drawbacks. A literature search was conducted focusing on the use of decoquinate against various infectious diseases in humans and animals. The search was conducted in several databases, including scientific and patent databases. Pharmaceutical nanotechnology and medicinal chemistry are the tools of choice to achieve human applications, and most of these applications have been able to improve the biopharmaceutical properties and pharmacokinetic profile of DQ. Based on the results presented here, DQ prototypes could be tested in clinical trials for human application in the coming years.
Palavras-chave
DecoquinatoAntimicrobiano
Propriedades físico-químicas
Química Medicinal
Nanomedicamentos
Palavras-chave em inglês
DecoquinateAntimicrobial
Physicochemical properties
Medicinal chemistry
Nanomedicines
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