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HUMAN GAMMAHERPESVIRUS 8 ONCOGENES ASSOCIATED WITH KAPOSI’S SARCOMA
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Niterói, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Niterói, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Abstract
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus
8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions,
including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection
and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF
72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9
(vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have
the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes
can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma.
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