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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12791]
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ABERRANT IL-17 LEVELS IN RODENT MODELS OF AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW
Transtorno do espectro do autismo
Modelos animais
Revisão sistemática
Inflamação
Autism spectrum disorder
Animal models
Systematic review
Inflammation
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Afiliação
Resumo em Inglês
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder
characterised by stereotyped behaviours, specific interests, and impaired
communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-
17A (IL-17A or IL-17), have been implicated as part of immune alterations that may
contribute to this outcome. In this context, rodent models have helped elucidate the role of
T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical
findings, the data available is contradictory in offspring but not in the pregnant dams,
pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD,
whilst there are no alterations described in IL-17 levels in others. To address this gap in the
literature, a systematic review of altered IL-17 levels in rodent models of ASD was
conducted. In total, 28 studies that explored IL-17 levels were included and observed
that this cytokine was generally increased among the different models of ASD. The data
compiled in this review can help the choice of animal models to study the role of cytokines
in the development of ASD, seeking a parallel with immune alterations observed in
individuals with this condition. Systematic Review Registration: PROSPERO, identifier CRD42022306558
Palavras-chave
IL-17Transtorno do espectro do autismo
Modelos animais
Revisão sistemática
Inflamação
Palavras-chave em inglês
IL-17Autism spectrum disorder
Animal models
Systematic review
Inflammation
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