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ANTISCHISTOSOMAL ACTIVITY OF AMINOALKANETHIOLS, AMINOALKANETHIOSULFURIC ACIDS AND THE CORRESPONDING DISULFIDES
Penido, Marcus Luiz de Oliveira et al. | Date Issued: 2008
Author
Penido, Marcus Luiz de Oliveira
Coelho, Paulo Marcos Zech
Mello, Rômulo Teixeira de
Piló-Veloso, Dorila
Oliveira, Mônica Cristina de
Kusel, John Robert
Nelson, David Lee
Affilliation
Departamento de Bioquímica-Imunologia. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Estado de Minas Gerais. Instituto Medicina Legal. Belo Horizonte, MG, Brazil
Fundacão Osvaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Santa Casa Hospital de Belo Horizonte. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Departamento de Produtos Farmacêuticas. Belo Horizonte, MG, Brazil
Department of Biochemistry. University of Glasgow. Glasgow, Scotland, United Kingdom
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Alimentos. Belo Horizonte, MG, Brazil
Abstract
This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the host animal, the aminoalkanethiosulfuric acids have a low toxicity and a high specificity for the adult female S. mansoni worms. In vitro studies with schistosomula, lung-phase schistosomula and adult worms have demonstrated effects on the tegument and the metabolism on these different stages of S. mansoni worms. The encapsulation of these drugs in a nanoemulsion has resulted in an increase in the in vitro activity. (C) 2008 Elsevier B.V. All rights reserved
Keywords
Schistosomicides
Aminoalkanethiols
Aminoalkanethiosulfates
Aminoalkyl disulfides
Schistosoma mansoni
Nanoemulsion
In vitro studies
 
Publisher
Elsevier
Citation
PENIDO, Marcus Luiz de Oliveira et al. Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides. Acta Trop., v. 108, n. 2-3, p. 249-55, 2008. doi: 10.1016/j.actatropica.2008.10.005.
DOI
10.1016/j.actatropica.2008.10.005
ISSN
0001-706X