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CHAMAECOSTUS SUBSESSILIS AND CHAMAECOSTUS CUSPIDATUS (NEES & MART) C.SPECHT AND D.W.STEV AS POTENTIAL SOURCES OF ANTICANCER AGENTS
Author
Affilliation
Laboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Department of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Laboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Zoo-Botanic Foundation of Belo Horizonte. Belo Horizonte, MG, Brazil
Pro-Rectory of Graduate and Research Program. Federal University of Jequitinhonha and Mucuri Valley. Diamantina, MG, Brazil
Department of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Laboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Department of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Laboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Zoo-Botanic Foundation of Belo Horizonte. Belo Horizonte, MG, Brazil
Pro-Rectory of Graduate and Research Program. Federal University of Jequitinhonha and Mucuri Valley. Diamantina, MG, Brazil
Department of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Laboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Abstract
Cytotoxicity activities of the crude ethanol extracts from Chamaecostus subsessilis and Chamaecostus cuspidatus and the fractions obtained by liquid-liquid partition were observed when these species were assayed against a panel of six human cancer cell lineages (HL60, Jurkat, MDA-MB231, MCF-7, HCT, THP-1) and normal (Vero) cells using the MTT colorimetric assay. The cytotoxic effects in the HL60, Jurkat and THP-1 lineages were mediated via an apoptotic mechanism when treated with crude ethanol extracts from these species. The presence of flavonoids, terpenoids and saponins in fractions from both species was observed in the preliminary phytochemical study. These results provide scientific support for the study of the Costaceae family and show that C. cuspidatus and C. subsessilis are potential sources of compounds with anticancer activities.
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