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SCHISTOSOMA MANSONI: MICROARRAY ANALYSIS OF GENE EXPRESSION INDUCED BY HOST SEX
Trematode
Microarray
Gene expression
Host sex
Host-parasite interaction
Autor(es)
Afiliação
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil
Universidade de Maryland. College Park, MD, Estados Unidos
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil
Universidade de Maryland. College Park, MD, Estados Unidos
Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil
Resumo em Inglês
Schistosoma mansoni is a digenetic trematode and a human parasite responsible for high social and economic impact. Although some authors have studied the effect of host hormones on parasites, not much is known about the effects of host sex on gene expression in Schistosomes. In order to study gene transcripts associated with the host sex, we compared the gene expression profiles of both male and female unisexual adult S. mansoni parasites raised on either male or female hosts, using DNA microarrays. Our results show that host sex caused differential expression of at least 11 genes in female parasites and of 134 in male parasites. Of the differentially expressed genes in female worms, 10 were preferentially expressed in female worms from male mice, while of the 134 differentially expressed genes in male parasites, 79 (59%) were preferentially expressed in worms from female mice. Further investigation of the role of each of those genes will help understand better their importance in the pathogenesis of Schistosomiasis. (C) 2008 Elsevier Inc. All rights reserved
Palavras-chave em inglês
Schistosoma mansoniTrematode
Microarray
Gene expression
Host sex
Host-parasite interaction
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