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NON-PERMISSIVE SARS-COV-2 INFECTION IN HUMAN NEUROSPHERES
https://www.arca.fiocruz.br/handle/icict/50755
Produção científica do Laboratório de Pesquisa sobre o Timo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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Abstract
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARSCoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
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bioRxiv
Later version
Citation
PEDROSA, Carolina da Silva Gouveia et al. Non-permissive SARS-CoV-2 infection in human neurospheres. BioRxiv, 34 p., 17 June 2021.DOI
10.1101/2020.09.11.293951Notes
Produção científica do Laboratório de Imunofarmacologia.Produção científica do Laboratório de Pesquisa sobre o Timo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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