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NEURO-INFLAMMATORY RESPONSE AND BRAIN-PERIPHERAL CROSSTALK IN SEPSIS AND STROKE
Bourhy, Lena et al. | Fecha del documento: 2022
Autor
Bourhy, Lena
Mazeraud, Aurélien
Bozza, Fernando A.
Turc, Guillaume
Lledo, Pierre-Marie
Sharshar, Tarek
Afiliación
Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.
Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France / Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Université de Paris. GHU Paris Psychiatrie et Neurosciences. Department of Neurology. Paris, France.
Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France.
Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France.
Resumen en ingles
Despite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There is renewed attention on peripheral inflammatory signaling as a way of modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been the focus for understanding the mechanisms of sickness behavior, which is an adaptive autonomic, neuroendocrine, and behavioral response to a peripheral inflammation. It is mediated by humoral and neural pathways that mainly involve the circumventricular organs and vagal nerve, respectively. In this review we address the question of how sepsis and stroke can dysregulate this adaptive response, notably by impairing the central integration of peripheral signaling, but also by efferent control of the immune response. We highlight the potential role of gut-brain and brain-spleen signaling in stroke.
Palabras clave en ingles
Immune response
Ischemic stroke
Neuromodulation
Sepsis
Sickness behavior
 
Editor
Frontiers Media
Referencia
BOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022.
DOI
10.3389/fimmu.2022.834649
ISSN
1664-3224