Por favor, use este identificador para citar o enlazar este ítem: https://www.arca.fiocruz.br/handle/icict/51602

Tipo
Artículo
Derechos de autor
Acceso restringido
Colecciones
Compartir

Estadísticas
Metadatos
Mostrar el registro completo del ítem

IMPACT OF HIV CO-INFECTION ON IMMUNOLOGICAL BIOMARKER PROFILE OF HTLV-1 INFECTED PATIENTS
Starling, Ana Lúcia Borges et al. | Fecha del documento: 2021
Autor
Starling, Ana Lúcia Borges
Pereira, Sílvio Roberto Souza
Pascoal, Vanessa Peruhype Magalhães
Reis, Jordana Grazziela Alves Coelho Dos
Bicalho, Kelly Alves
Paiva, Luciene Pimenta de
Martins, Julia Pereira
Trindade, Bruno Caetano
Labanca, Ludimila
Faccioli, Lúcia Helena
Lambertucci, José Roberto
Silva, Luciana Cristina Dos Santos
Antunes, Carlos Maurício de Figueiredo
Carvalho, Andréa Teixeira de
Proietti, Anna Bárbara de Freitas Carneiro
Gonçalves, Denise Ustch
Martins Filho, Olindo Assis
Afiliación
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.
Faculdade de Farmácia, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação HEMOMINAS. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Interdisciplinar de Pesquisa em HTLV. Belo Horizonte, MG, Brazil
Resumen en ingles
The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The plasma levels of leukotrienes and chemokines/cytokines were quantified by ELISA and Cytometric Bead Array. A total of 138 volunteers were enrolled and divided into two subgroups ("HTLV-1(+)HIV(-)" and "HTLV-1(+)(HIV(+)"), which were categorized according to the HTLV-1-associated neurological disease (AS, pHAM and HAM). Reference controls were BD and HIV mono-infected patients. HAM(+) exhibited higher CD4+ T-cell counts as compared to HIV+ mono-infected patients and lower HTLV-1 proviral load as compared to mono-infected HAM(-) patients. AS(+) exhibited higher levels of CysLT, CXCL8/IL-8 and lower levels of CCL5/RANTES as compared to AS(-). Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as compared to HAM(-) subgroup.
Palabras clave en ingles
Biomarkers
Chemokines
Cytokines
HTLV-1
HTLV-1/HIV co infection
Leukotrienes
 
Editor
Elsevier
Referencia
STARLING, Ana Lúcia Borges et al. Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients. Immunol Lett., v. 236, p. 68-77, 2021. doi: 10.1016/j.imlet.2021.05.009.
DOI
10.1016/j.imlet.2021.05.009.
ISSN
0165-2478