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GRAPHENE QUANTUM DOTS DECORATED WITH IMATINIB FOR LEUKEMIA TREATMENT
Mendes, Felix Daniele et al. | Date Issued: 2021
Author
Mendes, Felix Daniele
Alencar, Luciana Magalhães Rebelo
Menezes, Frederico Duarte de
Midlej, Victor do Valle Pereira
Aguiar, Lorayne
Piperni, Sara Gemini
Zhang, Jian
Liu, Yin
Ricci-Junior, Eduardo
Alexis, Frank
Alves Junior, Severino
Zhu, Lin
Santos-Oliveira, Ralph
Affilliation
Brazilian Nuclear Energy Commission. Nuclear Engineering Institute. Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals. Rio de Janeiro, RJ, Brazil.
Federal University of Maranhão. Department of Physics. São Luis, MA, Brazil.
Federal Institute of Education. Science and Technology of Pernambuco. Recife, PE, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Cellular Ultrastructure. Rio de Janeiro, RJ, Brazil.
Unigranrio. Laboratory of Multidisciplinary Studies. Rio de Janeiro, RJ, Brazil.
Unigranrio. Laboratory of Multidisciplinary Studies. Rio de Janeiro, RJ, Brazil.
Department of Pharmaceutical Sciences. Irma Lerma Rangel College of Pharmacy. Texas A&M University. Texas, USA.
Department of Pharmaceutical Sciences. Irma Lerma Rangel College of Pharmacy. Texas A&M University. Texas, USA.
Federal University of Rio de Janeiro. College of Pharmacy. Rio de Janeiro, RJ, Brazil.
School of Biological Sciences and Engineering. Yachay Tech University. Urcuquí, Imbabura, Ecuador.
Universidade Federal de Pernambuco. Centro de Ciências Exatas e da Natureza. Departamento de Química. Laboratório de Terras Raras. Recife, PE, Brazil.
Department of Pharmaceutical Sciences. Irma Lerma Rangel College of Pharmacy. Texas A&M University. Texas, USA.
Brazilian Nuclear Energy Commission. Nuclear Engineering Institute. Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals. Rio de Janeiro, RJ, Brazil.
Abstract
The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nanoplatform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles’ in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.
Keywords
Drug delivery
Graphene quantum dot
Biomedical device
Smart material
Nanoparticle
 
Citation
FELIX, Daniele Mendes et al. Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, [S. l.], v. 61, p. 1-19, 2021.
DOI
10.1016/j.jddst.2020.102117
ISSN
1773-2247